Mary J. Bossard - Madison AL, US Steven O. Roczniak - Greensboro NC, US Harold Zappe - Harvest AL, US Yujun Wang - Madison AL, US Ping Zhang - Madison AL, US Dawei Sheng - Madison AL, US C. Simone Jude-Fishburn - Redwood City CA, US Elizabeth Louise Minamitani - Lacey's Spring AL, US Xiaofeng Liu - Union City CA, US Haim Moskowitz - San Diego CA, US Dennis G. Fry - Huntsville AL, US Cherie F. Ali - Burlingame CA, US Christine Taylor Brew - Pacifica CA, US
The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
Dawei Sheng - Madison AL, US Harold Zappe - Harvest AL, US C. Simone Jude-Fishburn - Redwood City CA, US Steven O. Roczniak - Greensboro NC, US Mary J. Bossard - Madison AL, US
Assignee:
Nektar Therapeutics - San Francisco CA
International Classification:
A61K 47/48 C08G 65/48 A61P 29/00
US Classification:
424 7817, 525 541
Abstract:
The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
Samuel P. McManus - Huntsville AL, US Timothy A. Riley - Huntsville AL, US Sean M. Culbertson - Gurley AL, US Antoni Kozlowski - Huntsville AL, US Dennis G. Fry - Huntsville AL, US Xuejun Yuan - Huntsville AL, US Dawei Sheng - Madison AL, US Vidula R. Dixit - Madison AL, US
The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
Methods And Compositions For Detecting One Or More Target Agents Using Tracking Components
I-Min M. Jen - Sunnyvale CA, US Mark O. Trulson - San Jose CA, US Kilian Dill - La Honda CA, US Marc R. Labgold - Reston VA, US Dawei Sheng - Mountain View CA, US George G. Jokhadze - Mountain View CA, US Chandramohan V. Ammini - Mountain View CA, US Peter Lobban - Los Altos Hills CA, US
The present invention provides devices and methods for real time detection of target agents in a sample. These devices utilize tracking technology and selective binding to allow the identification of one or more target agents in a sample, and preferably in a biological sample. The present invention provides specific embodiments employing radio frequency identification devices.
Fluorescent Energy Transfer Labeled Nucleic Acid Substrates And Methods Of Use Thereof
Dawei Sheng - Mountain View CA, US Marcia Tan - Palo Alto CA, US Robert Larsen - Alameda CA, US
International Classification:
C12Q001/68
US Classification:
435006000
Abstract:
Methods and compositions for detecting a target nucleic acid in a sample are provided. Also provided are methods and compositions for detecting a plurality of target nucleic acids in a sample. Sets of components for use in a subject method are provided; as well as compositions that include a subject set. The invention further provides kits and systems for practicing the subject methods
Conjugates Of A Factor Viii Moiety Having An Oxime-Containing Linkage
The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer. Methods for preparing and for administering such conjugates, are also provided, as are water-soluble polymer oxyamine reagents useful for preparing the subject conjugates, among other things.
- San Francisco CA, US Steven O. Roczniak - Prescott AZ, US Harold Zappe - Harvest AL, US Yujun Wang - Fremont CA, US Ping Zhang - Millbrae CA, US Dawei Sheng - Fremont CA, US C. Simone Jude-Fishburn - Redwood City CA, US Elizabeth Louise Minamitani - Lacey's Spring AL, US Xiaofeng Liu - Belmont CA, US Haim Moskowitz - San Diego CA, US Dennis G. Fry - Pacifica CA, US Cherie F. Ali - Burlingame CA, US Christine Taylor Brew - Pacifica CA, US
The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
- San Francisco CA, US Steven O. Roczniak - Greensboro NC, US Harold Zappe - Harvest AL, US Yujun Wang - Fremont CA, US Ping Zhang - Millbrae CA, US Dawei Sheng - Madison AL, US C. Simone Jude-Fishburn - Redwood City CA, US Elizabeth Louise Minamitani - Lacey's Spring AL, US Xiaofeng Liu - Belmont CA, US Haim Moskowitz - San Diego CA, US Dennis G. Fry - Pacifica CA, US Cherie F. Ali - Burlingame CA, US Christine Taylor Brew - Pacifica CA, US
International Classification:
A61K 47/48 A61K 38/16
Abstract:
The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
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