Keith Hildebrand - Houlton WI, US Linda Page - Woodbury MN, US Deanna Lane - Columbia Heights MN, US Dennis Elsberry - Plymouth MN, US David Clarahan - Blaine MN, US Harris Ratnayake - Blaine MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K031/195
US Classification:
514561000, 604890100
Abstract:
A system including a reservoir, a pump coupled to the reservoir, a catheter coupled to the pump and adapted for delivering a therapeutic agent to a cerebrospinal fluid of a patient; and an injectable gabapentin composition housed in the reservoir and deliverable through the catheter, is discussed. The injectable gabapentin composition may have reduced tonicity. One such injectable gabapentin composition contains greater than about 30 mg/ml gabapentin and has a tonicity of less than about 900 mOsm. Another such injecable gabapentin composition contains less that 0.9% sodium chloride.
Process For Producing Injectable Gabapentin Compositions
Keith Hildebrand - Houlton WI, US Linda Page - Woodbury MN, US Deanna Lane - Columbia Heights MN, US Dennis Elsberry - Plymouth MN, US David Clarahan - Blaine MN, US Jayantha Ratnayake - Blaine MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K031/195
US Classification:
514561000
Abstract:
Injectable compositions containing gabapentin and processes for preparing sterile injectable compositions containing gabapentin are discussed. The process includes subjecting the compositions to heat. Heating results in increased production of gabapentin lactam, which has previously been shown to be toxic. Surprisingly, heated injectable compositions containing gabapentin are found to be non-toxic when administered intrathecally. Thus, heating for the purposes of sterilization or to assure sterility provides a viable option in the production of injectable compositions containing gabapentin.
Keith Hildebrand - Houlton WI, US Linda Page - Woodbury MN, US Deanna Lane - Columbia Heights MN, US Dennis Elsberry - Plymouth MN, US David Clarahan - Blaine MN, US Jayantha Ratnayake - Blaine MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K031/195
US Classification:
514561000
Abstract:
Injectable compositions containing gabapentin and having reduced tonicity are discussed. One such injectable gabapentin composition contains greater than about 30 mg/ml gabapentin and has a tonicity of less than about 900 mOsm. Another such injecable gabapentin composition contains less that 0.9% sodium chloride. A process for preparing injectable gabapentin compositions are also discussed. The process includes determining and optionally adjusting tonicity of a gabapentin composition.
Keith Hildebrand - Houlton WI, US Linda Page - Woodbury MN, US Deanna Lane - Columbia Heights MN, US Dennis Elsberry - Plymouth MN, US David Clarahan - Blaine MN, US Jayantha Ratnayake - Blaine MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K031/195 A61M031/00
US Classification:
514561000, 604500000
Abstract:
Methods for treating epilepsy by administering gabapentin to cerebrospinal fluid and brain tissue of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable device having a pump coupled to a reservoir for housing a composition, a catheter having a proximal end coupled to the pump and having a distal end adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, are also discussed.
Keith Hildebrand - Houlton WI, US Linda Page - Woodbury MN, US Deanna Lane - Columbia Heights MN, US Dennis Elsberry - Plymouth MN, US David Clarahan - Blaine MN, US Jayantha Ratnayake - Blaine MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K031/195 A61M031/00
US Classification:
514561000, 604500000
Abstract:
Methods for treating pain by administering gabapentin to cerebrospinal fluid of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable pump having a reservoir for housing a composition, a catheter having a proximal portion coupled to the pump and having a distal portion adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, is also discussed.
Keith Hildebrand - Houlton WI, US Linda Page - Woodbury MN, US Deanna Lane - Columbia Heights MN, US Dennis Elsberry - Plymouth MN, US David Clarahan - Blaine MN, US Jayantha Ratnayake - Blaine MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K 31/195 A61K 9/22
US Classification:
514561000, 604890100
Abstract:
Methods for treating epilepsy by administering gabapentin to cerebrospinal fluid and brain tissue of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable device having a pump coupled to a reservoir for housing a composition, a catheter having a proximal end coupled to the pump and having a distal end adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, are also discussed.
Keith Hildebrand - Houlton WI, US Linda Page - Woodbury MN, US Deanna Lane - Columbia Heights MN, US Dennis Elsberry - Plymouth MN, US David Clarahan - Blaine MN, US Jayantha Ratnayake - Blaine MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K 31/195 A61K 9/22
US Classification:
514561000, 604890100
Abstract:
Methods for treating pain by administering gabapentin to cerebrospinal fluid of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable pump having a reservoir for housing a composition, a catheter having a proximal portion coupled to the pump and having a distal portion adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, is also discussed.
Process For Producing Injectable Gabapentin Compositions
Keith Hildebrand - Houlton WI, US Linda Page - Woodbury MN, US Deanna Lane - Columbia Heights MN, US Dennis Elsberry - Plymouth MN, US David Clarahan - Blaine MN, US Jayantha Ratnayake - Blaine MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61K 31/195
US Classification:
514561000
Abstract:
Injectable compositions containing gabapentin and processes for preparing sterile injectable compositions containing gabapentin are discussed. The process includes subjecting the compositions to heat. Heating results in increased production of gabapentin lactam, which has previously been shown to be toxic. Surprisingly, heated injectable compositions containing gabapentin are found to be non-toxic when administered intrathecally. Thus, heating for the purposes of sterilization or to assure sterility provides a viable option in the production of injectable compositions containing gabapentin.
Garris Robert Realtors 3146 Brockway Road, Waterloo, IA 50701 3195299638 (Phone), 3198834234 (Cell), 3192341445 (Fax)
Description:
DeAnna grew up in Waterloo, graduated from West High School and has a Masters Degree in Business Administration from the University of Northern Iowa. She retired from Deere & Company as an Information Technology Business Analyst. DeAnna brings a strong work ethic, an attention to detail and a dedication to help others reach their real estate goals. MemberWaterloo/Cedar Falls Board of Realtors Member Multiple Listing Services Committee Member Appraisal Committee Member Iowa Association of Realtors Member of National Association of Realtors Member of Council of Residential Specialists Participating in fast track program to obtain CRS certification. Member Iowa Chapter of Council of Residential Specialists