Deborah L. Bryan - King of Prussia PA, US Joelle L. Burgess - Collegeville PA, US James F. Callahan - Collegeville PA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 31/47 C07D 215/38 C07D 215/12
US Classification:
546161, 546167, 546159, 514311, 514314
Abstract:
This invention relates to novel quinoline inhibitors of hYAK1 and hYAK3 kinases and pharmaceutically acceptable salts, hydrates or solvates thereof, pharmaceutical compositions thereof, and methods of treatment of diseases in which an excessive amount of either such kinase is a factor.
4-Amino-2,3-Disubstituted Thieno[2,3-D]Pyrimidines And Pharmacetical Compositions Thereof
Jerry Leroy Adams - King of Prussia PA, US Deborah Lynne Bryan - King of Prussia PA, US Yanhong Feng - Collegeville PA, US Shinichiro Matsunaga - Tsukuba, JP Yutaka Maeda - Tsukuba, JP Yasushi Miyazaki - Tsukuba, JP Masato Nakano - Tsukuba, JP Jean-Philippe Rocher - Vetraz-Mothoux, FR Hideyuki Sato - Tsukuba, JP Marcus Semones - Collegeville PA, US Domingos J. Silva - Collegeville PA, US Jun Tang - Tsukuba, JP
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 31/519 C07D 495/04 A61P 35/00 A61P 9/00
US Classification:
5142601, 544278
Abstract:
Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
Jerry L. Adams - King of Prussia PA, US Deborah L. Bryan - King of Prussia PA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 31/4439 C07D 401/04
US Classification:
514341, 5462741
Abstract:
The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
Jeffrey Michael Axten - Collegeville PA, US Deborah L. Bryan - Collegeville PA, US David Harold Drewry - Durham NC, US Thomas H Faitg - Collegeville PA, US Timothy Francis Gallagher - Collegeville PA, US Neil W Johnson - Collegeville PA, US Jiri Kasparec - Collegeville PA, US Jeffrey M Ralph - Collegeville PA, US Domingos J. Silva - Collegeville PA, US
The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
Jerry Adams - Collegeville PA, US Deborah Bryan - King of Prussia PA, US Jiri Kasparec - King of Prussia PA, US Francis King - King of Prussia PA, US Andrew Takle - King of Prussia PA, US David Wilson - King of Prussia PA, US Steven Goodman - King of Prussia PA, US
International Classification:
A61K 31/4439 C07D 403/02
US Classification:
514337000, 546277400
Abstract:
Pyridinyl-benzoheterocycyl kinase inhibitor compounds are disclosed. Also disclosed are methods of making such compounds as well as methods of using the same in the treatment of diseases.