Deborah J Downs

US Patent:

20090214554, Aug 27, 2009

Filed:

Sep 17, 2008

Appl. No.:

12/212539

Inventors:

Wan Pin CHANG - Edmond OK, US
Deborah Downs - Oklahoma City OK, US
Jordan J.N. Tang - Edmond OK, US

Assignee:

Oklahoma Medical Research Foundation - Oklahoma City OK

International Classification:

A61K 39/395
A61K 38/16
A61P 25/28
C07K 16/18
A61K 31/7088

US Classification:

4241391, 514 12, 5303879, 5303873

Abstract:

The present invention provides novel methods of reducing memapsin 2 β-secretase activity in a subject, decreasing levels of β-amyloid peptide in the brain of a subject, treating Alzheimer's disease and/or reducing the size and/or number of β-amyloid plaques in the brain of a subject. The methods may include the step of administering an effective amount of truncated memapsin 2 protein, anti-truncated memapsin 2 antibody, and/or nucleic acid encoding a truncated memapsin 2 protein or anti-truncated memapsin 2 antibody. The present invention also provides related pharmaceutical compositions and uses thereof.

US Patent:

20130261052, Oct 3, 2013

Filed:

Mar 11, 2013

Appl. No.:

13/794031

Inventors:

Jordan Tang - Oklahoma City OK, US
Xiangping Huang - Oklahoma City OK, US
Deborah Downs - Oklahoma City OK, US

Assignee:

Oklahoma Medical Research Foundation - Oklahoma City OK

International Classification:

C07D 239/84
C07D 417/12
C07C 311/08
C07D 513/04
C07D 241/04
C07K 5/02
C07D 403/12
C07D 413/12

US Classification:

514 69, 5142662, 5142661, 51421108, 51425212, 514616, 435184

Abstract:

Proteases such as memapsin-1 are import enzymes, playing roles in a variety of diseases including diabetes. The inventors have developed inhibitors of memapsin 1 and methods of use therefore in the treatment of disease.

US Patent:

20070092517, Apr 26, 2007

Filed:

Aug 9, 2006

Appl. No.:

11/463501

Inventors:

Wan Chang - Edmond OK, US
Deborah Downs - Oklahoma City OK, US
Jordan Tang - Edmond OK, US

Assignee:

Oklahoma Medical Research Foundation - Oklahoma City OK

International Classification:

A61K 39/395
C07K 14/47
C07K 16/18

US Classification:

424145100, 514012000, 530388250

Abstract:

The present invention provides novel methods of reducing memapsin 2 β-secretase activity in a subject, decreasing levels of β-amyloid peptide in the brain of a subject, treating Alzheimer's disease and/or reducing the size and/or number of β-amyloid plaques in the brain of a subject. The methods may include the step of administering an effective amount of truncated memapsin 2 protein, anti-truncated memapsin 2 antibody, and/or nucleic acid encoding a truncated memapsin 2 protein or anti-truncated memapsin 2 antibody. The present invention also provides related pharmaceutical compositions and uses thereof.