Deborah L Moore

US Patent:

7101547, Sep 5, 2006

Filed:

Jan 14, 2000

Appl. No.:

09/889317

Inventors:

Ralph A. Tripp - Decatur GA, US
Larry J. Anderson - Atlanta GA, US
Deborah D. Moore - Marietta GA, US

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

A61K 39/395

US Classification:

4241301, 4241331, 5303871, 53038824, 5303892

Abstract:

The present invention provides methods for preventing or treating a disease in a subject which is caused by an inflammatory response to a disease or syndrome which is mediated by endogenous substance P. These methods comprise the administration to the subject of a pharmaceutically-effective amount of anti-substance P antibodies, or anti-substance P antibody fragments, such as F(ab)fragments, thereby inhibiting the activity of endogenous substance P in the subject. By inhibiting the activity of endogenous substance P in the subject, the levels of cytokines produced by T lymphocytes present in the subject are reduced, the signals which direct the inflammatory response to the infection become altered, and the amount of cytokine-induced inflammation becomes reduced. Respiratory syncytial virus is one example of an agent which causes an infection which often results in a disease caused by an inflammatory response to the infection mediated by endogenous substance P. Generally, from about 0.