James B. Doherty - New Milford NJ Conrad P. Dorn - Plainfield NJ Bruce E. Witzel - Westfield NJ Debra L. Allison - Scotch Plains NJ Tsung-Ying Shen - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3155 C07D20994 C07D491044
US Classification:
424274
Abstract:
Tricyclic derivatives of substituted pyrrole acids, e. g. , substituted 4,10-dihydro-10-oxo-1H-[1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the 5-thia analogs thereof have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to have high analgesic and anti-inflammatory activities but low ulcerogenic side effects.