Debra D Bloom

US Patent:

6709840, Mar 23, 2004

Filed:

May 11, 2001

Appl. No.:

09/854300

Inventors:

Gregory Ford - Sunnyvale CA
Debra Bloom - Sun Prairie WI
C. Garrison Fathman - Stanford CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

C07H 2104

US Classification:

435 691, 4352523, 4353201, 536 235, 536 2431, 536 2433

Abstract:

Isolated nucleic acid compositions and sequences of anergy associated genes are provided, including the novel GRAIL gene. Expression of these genes is upregulated during the early stages of induction of anergy. The murine GRAIL sequence is shown to attenuate IL-2 transcription in T cells during response to antigenic stimulation. The identification of genes involved in the induction of anergy is useful in the evaluation of the pathophysiology or immunotherapy of cancer, autoimmune disease, and transplant rejection. Genetic sequences involved in anergy induction are useful markers in the evaluation of specific immunotherapies. Functional characterization of genes involved in anergy induction allows the elucidation of the mechanism(s) of T cell anergy, including the transcriptional blockade of IL-2, which may be manipulated to regulate T cell responses in human disease. The signaling pathways involving GRAIL are of significant interest in the identification of drugs that either block or upregulate the function(s) of GRAIL.

US Patent:

20120264142, Oct 18, 2012

Filed:

Oct 25, 2010

Appl. No.:

13/501671

Inventors:

Debra D. Bloom - Sun Prairie WI, US
Hans W. Sollinger - Madison WI, US
Arjang Djamali - Cross Plains WI, US

Assignee:

WISCONSIN ALUMNI RESEARCH FOUNDATION - Madison WI

International Classification:

G01N 33/566

US Classification:

435 724, 435 792

Abstract:

The invention relate to methods, compositions, and kits for detection of biomarkers. hi one embodiment, the invention relates to a method for detecting AMR biomarkers in a biological sample. In another embodiment, the invention relates to a method for detecting, monitoring, diagnosing and predicting antibody mediated rejection. In yet another embodiment, the invention relates to a method for monitoring a subject for antibody mediated rejection comprising detecting BAFF or a BAFF variant in a biological sample. In still another embodiment, the invention relates to a kit for detecting BAFF in a urine sample.

US Patent:

57472998, May 5, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/486955

Inventors:

Debra Bloom - Mountain View CA
C. Garrison Fathman - Portola Valley CA
Sarah Slaymaker - Stanford CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA

International Classification:

C12P 1934
C12Q 168
G01N 3300
C07H 2102

US Classification:

435 912

Abstract:

Methods and compositions are provided for identifying genes associated with induction of anergy in T-cells and the use of the nucleic acids or proteins as diagnostics for monitoring induction of tolerance for the presence of tolerized T-cells in a physiological sample, or elucidating the pathway to anergy or activation in T-cells. A cysteine string protein is found to indicate quiescent T-cells and is lost with anergic T-cells.

US Patent:

20170260506, Sep 14, 2017

Filed:

Mar 14, 2017

Appl. No.:

15/458339

Inventors:

- Madison WI, US
Debra Bloom - Sun Prairie WI, US

International Classification:

C12N 5/0783
A61K 9/00
A61K 35/17
A61K 39/00

Abstract:

The present disclosure relates to methods, cells, and compositions for preparing T cell populations and compositions for adoptive cell therapy. In particular, provided herein are methods for efficiently expanding and activating T cell populations for genetic engineering and adoptive T cell immunotherapies. Also provided are cells and compositions produced by the methods and methods of their use.