Debra L Dunlap

US Patent:

20030157523, Aug 21, 2003

Filed:

Nov 20, 2002

Appl. No.:

10/300546

Inventors:

Gretchen Frantz - San Francisco CA, US
Trent Landon - San Francisco CA, US
Thinh Pham - San Bruno CA, US
Jean Stephan - San Carlos CA, US
Debra Dunlap - Sunnyvale CA, US
Kenneth Hillan - San Francisco CA, US

Assignee:

GENENTECH, INC.

International Classification:

C12Q001/68
G01N033/53
G01N033/567
G01N033/574
B28B001/48
B29D019/08
C12M001/34

US Classification:

435/006000, 435/007200, 435/007230, 435/287200, 264/155000

Abstract:

The invention relates to biological arrays, biological microarrays, and methods of using the arrrays and microarrays to detect the amount and/or presence of a biological molecule in a biological sample. Biological arrays of the invention comprise a solidified, sectionable matrix comprising a plurality of wells disposed therein and one or more biological samples disposed within the plurality of wells, which biological arrays optionally comprise an internal standard preparation and/or an orientation marker. Sections or slices of the biological arrays are mounted on a planar substrate surface to form cellular microarrays of the invention. In alternative cellular microarrays of the invention, the matrix material is a temperature-sensitive material removable from the microarray leaving cellular biological material on the substrate surface.

US Patent:

20200292536, Sep 17, 2020

Filed:

May 29, 2020

Appl. No.:

16/888252

Inventors:

- South San Francisco CA, US
Charles HAVNAR - Pacifica CA, US
Linda RANGELL - Pacifica CA, US
Debra Y. DUNLAP - Redwood City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

G01N 33/543
G01N 1/36
G01N 1/30

Abstract:

The present disclosure relates to synthetic controls useful, e.g., for immunohistochemistry (IHC), as well as kits and methods of manufacture and use related thereto. In some embodiments, the synthetic controls include a solid antigen/carrier protein gel comprising a purified antigen (e.g., at a known quantity) and a carrier protein such as an albumin protein (e.g., a serum albumin protein), an egg white protein or mixture of egg white proteins, gelatin, or poly-lysine. In some embodiments, the purified antigen is cross-linked to the carrier protein in the solid antigen/carrier protein gel.