Debra Lee Mills

US Patent:

20190292165, Sep 26, 2019

Filed:

Dec 5, 2017

Appl. No.:

16/348033

Inventors:

- Worcester MA, US
- Bronx NY, US
- Fort Detrick MD, US
John M. Dye - Frederick MD, US
John D. Williams - Fulton MD, US
Zachary D. Aron - Acton MA, US
Jay P. Barbor - Worcester MA, US
Kelly N. Lively - Holliston MA, US
Peter J. Nash - Newton MA, US
Debra M. Mills - Francestown NH, US
Arnab Basu - Acton MA, US

Assignee:

Microbiotix, Inc. - Worcester MA
Albert Einstein College Of Medicine, Inc. - Bronx NY
The Govermnment Of The United States As Represented By The Secretary Of The Army - Fort Detrick MD

International Classification:

C07D 401/04
A61P 31/14
C07D 403/04
C07D 401/14

Abstract:

The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GP) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.