Dejian Ren

US Patent:

7790845, Sep 7, 2010

Filed:

Nov 5, 2002

Appl. No.:

10/494783

Inventors:

David Clapham - Wellesley MA, US
Dejian Ren - Wynnewood PA, US

Assignee:

Children's Medical Center Corporation - Boston MA

International Classification:

C07K 14/195

US Classification:

530350, 530825

Abstract:

The present invention relates to a functionally expressed bacterial voltage-sensitive ion-selective channel. The novel channel can be used in conjunction with mammalian ion channel pore-containing regions in assays for screening for compounds that modulate activity of the channel. One bacterial ion channel of the present invention, called NaChBac, is derived from (GenBank#BAB05220 (8)).

US Patent:

8211666, Jul 3, 2012

Filed:

Oct 30, 2003

Appl. No.:

10/697863

Inventors:

David E. Clapham - Wellesley MA, US
Dejian Ren - Wynnewood PA, US

Assignee:

Children's Medical Center Corporation - Boston MA

International Classification:

C12N 15/00
C12N 15/85
C12N 5/06
C12N 1/21
C12N 5/08
C12N 1/19
C07H 21/04
C07K 14/00

US Classification:

435 691, 4353201, 435325, 4352521, 435348, 435366, 4352542, 536 231, 536 235, 530350

Abstract:

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.

US Patent:

20050142566, Jun 30, 2005

Filed:

Apr 21, 2004

Appl. No.:

10/828975

Inventors:

Dejian Ren - Wynnewood PA, US
David Clapham - Wellesley MA, US
David Garbers - Dallas TX, US
Timothy Quill - Grapevine TX, US

Assignee:

Children's Medical Center Corporation - Boston MA
Board of Regents, The University of Texas System - Austin TX

International Classification:

C12Q001/68
C07H021/04
C07K014/705
C07K016/28

US Classification:

435006000, 435069100, 435320100, 435325000, 530350000, 536023500, 530388220

Abstract:

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.

US Patent:

20090104604, Apr 23, 2009

Filed:

Jan 29, 2008

Appl. No.:

12/021474

Inventors:

Dejian REN - Wynnewood PA, US
David CLAPHAM - Wellesley MA, US
David L. GARBERS - Denton TX, US
Timothy A. QUILL - Grapevine TX, US

Assignee:

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

C12Q 1/68
C07H 21/00
C12N 15/63
C12N 5/10
C12N 1/21
C12N 1/19

US Classification:

435 6, 536 235, 4353201, 435348, 435352, 435366, 435325, 4352523, 4352542

Abstract:

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.

US Patent:

20130102495, Apr 25, 2013

Filed:

May 30, 2012

Appl. No.:

13/484061

Inventors:

David E. CLAPHAM - Wellesley MA, US
Dejian REN - Wynnewood PA, US

Assignee:

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

International Classification:

G01N 33/68

US Classification:

506 10, 435 611, 435 721, 435 29

Abstract:

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.

US Patent:

20170107269, Apr 20, 2017

Filed:

Aug 19, 2016

Appl. No.:

15/241470

Inventors:

- Boston MA, US
Dejian REN - Wynnewood PA, US

International Classification:

C07K 14/705
G01N 33/50
A01K 67/027

Abstract:

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.

US Patent:

20150219629, Aug 6, 2015

Filed:

Sep 2, 2014

Appl. No.:

14/474907

Inventors:

- Boston MA, US
Dejian REN - Wynnewood PA, US

Assignee:

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

International Classification:

G01N 33/50

Abstract:

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.