Denise E Andersen

US Patent:

20220274969, Sep 1, 2022

Filed:

Jul 16, 2020

Appl. No.:

17/627590

Inventors:

- South San Francisco CA, US
Denise ANDERSEN - Montara CA, US

International Classification:

C07D 413/12

Abstract:

Provided herein are polymorphs of (R)—N-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-2-methyl-2H-tetrazole-5-carboxamide, compositions thereof, methods of preparation thereof, and methods of their uses.

US Patent:

20230083960, Mar 16, 2023

Filed:

Nov 5, 2021

Appl. No.:

17/453761

Inventors:

- South San Francisco CA, US
Chris Evans - South San Francisco CA, US
Pu-Ping Lu - South San Francisco CA, US
Makoto Yamasaki - South San Francisco CA, US
Wenyue Wang - South San Francisco CA, US
Scott Collibee - South San Francisco CA, US
Takuya Makino - Tokyo, JP
Kazuyuki Tsuchiya - Tokyo, JP
Toshio Kurosaki - Tokyo, JP
Susumu Yamaki - Tokyo, JP
Eriko Honjo - Tokyo, JP
Yuka Koizumi - Tokyo, JP
Naoto Katoh - Tokyo, JP
Ryuichi Sekioka - Tokyo, JP
Ikumi Kuriwaki - Tokyo, JP
Denise Andersen - South San Francisco CA, US

International Classification:

C07D 243/14
C07D 471/04
C07D 487/04
C07D 498/04
C07D 405/14
C07D 401/12
C07D 403/14
C07D 519/00
C07D 413/12
C07D 471/10
C07D 417/12
C07D 413/08

Abstract:

Provided herein are compounds of formula (I):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X, X, R, R, R, R, R, and Rare as defined herein.Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing.Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

US Patent:

20190127404, May 2, 2019

Filed:

Nov 16, 2018

Appl. No.:

16/193160

Inventors:

- Austin TX, US
Mark Matteucci - Portola Valley CA, US
Nipun Davar - Pleasanton CA, US
Denise Andersen - Montara CA, US

Assignee:

Molecular Templates, Inc. - Austin TX

International Classification:

C07F 9/6506
A61K 31/675
A61K 31/664
A61K 45/06

Abstract:

The present invention provides a new method for making TH-302 and solid forms thereof. The compound in its solid form is an effective anti-cancer agent and may be used in various pharmaceutical compositions, and are particularly effective for the treatment of cancer. The invention also provides a method for preparing such compounds and forms and for treating cancer in a mammal comprising the step of administering a therapeutically effective amount of a solid form of TH-302 thereof.

US Patent:

20170210769, Jul 27, 2017

Filed:

Jul 15, 2015

Appl. No.:

15/326990

Inventors:

- South San Francisco CA, US
Mark Matteucci - Portola Valley CA, US
Nipun Davar - Pleasanton CA, US
Denise Andersen - Montara CA, US

Assignee:

THRESHOLD PHARMACEUTICALS, INC. - South San Francisco CA

International Classification:

C07F 9/6506
A61K 31/675

Abstract:

The present invention provides a new method for making TH-302 and solid forms thereof. The compound in its solid form is an effective anti-cancer agent and may be used in various pharmaceutical compositions, and are particularly effective for the treatment of cancer. The invention also provides a method for preparing such compounds and forms and for treating cancer in a mammal comprising the step of administering a therapeutically effective amount of a solid form of TH-302 thereof.