Denong N Wang from 855 Altaire Walk, Palo Alto, CA 94303, age 70, Phone: 8455483857

Resumes

Senior Program Director

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Location:

Palo Alto, CA

Industry:

Biotechnology

Work:

Sri International
Senior Program Director
Stanford University School of Medicine Jan 2004 - Jan 2010
Senior Research Scientist
Columbia University Genome Center Jan 1998 - Jan 2004
Head, Functional Genomics
Columbia University Medical Center Jan 1995 - Jan 1998
Aaron Diamond Postdoctoral Fellow

Education:

Stanford University 1993 - 1994
Columbia University In the City of New York 1990 - 1991
Masters, Molecular Biology Columbia University In the City of New York 1989 - 1990
Doctorates, Masters, Master of Arts, Doctor of Philosophy, Microbiology, Immunology Anhui Medical University 1979 - 1982
Masters, Immunology Anhui Medical College 1976 - 1979
Hefei No.8 Senior High School
Anhui Medical University
Columbia University

Skills:

Molecular Biology
Biotechnology
Life Sciences
Biochemistry
Immunology
Research
Cell Culture
Science
Protein Chemistry
Cell Biology
Assay Development
Drug Discovery

Languages:

English
Mandarin

Certifications:

Ph.d.

Denong Wang

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Us Patents

Prostate Cancer Glycan Markers And Autoantibody Signatures
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US Patent:

7981625, Jul 19, 2011
Filed:

Apr 10, 2009
Appl. No.:

12/421964
Inventors:

Denong Wang - Palo Alto CA, US
Leonore A. Herzenberg - Stanford CA, US
Donna M. Peehl - Mountain View CA, US
Leonard A. Herzenberg - Palo Alto CA, US
Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:

G01N 33/53
US Classification:

435 71, 435 72, 436518
Abstract:

Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally “cryptic. ” This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues include lectin (EEL); Lectin-I (PTL-I); Lectin-I-A4 (GSL-I-A4); Lectin-I-B4 (GSL-I-B4); I agglutinin (SNA-I; -L (PHA-L; agglutinin (GNA); agglutinin (NPA); agglutinin (Jacalin); and mAb TM10 (IgM).

Photochemical Methods And Photoactive Compounds For Modifying Surfaces
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US Patent:

8158832, Apr 17, 2012
Filed:

Nov 9, 2006
Appl. No.:

11/595292
Inventors:

Gregory T. Carroll - New York NY, US
Denong Wang - Palo Alto CA, US
Nicholas J. Turro - New York NY, US
Jeffrey T. Koberstein - Storrs CT, US
Assignee:

The Trustees of Columbia University in the City of New York - New York NY
International Classification:

C07C 49/303
US Classification:

568332
Abstract:

Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.

Novel Microarrays And Methods Of Use Thereof
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US Patent:

20030228637, Dec 11, 2003
Filed:

Oct 24, 2002
Appl. No.:

10/280376
Inventors:

Denong Wang - Middletown NY, US
Assignee:

The Trustees of Columbia University in the City of New York
International Classification:

G01N033/53
G01N033/542
C12M001/34
US Classification:

435/007900, 435/287200
Abstract:

This invention provides novel nitrocellulose-based or Hydrogel-based microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, (3) to determine whether a subject is afflicted with a disorder, and (4) to determine whether an agent known to specifically bind to a first compound also specifically binds to a second compound. This invention also provides kits which comprise the instant microarrays. This invention further provides antibodies capable of specifically binding to a glycomer present both on the surface of a mammalian macrophage or intestinal epithelial cell, and on a bacterial cell. Finally, this invention provides diagnostic methods using the instant antibodies.

Novel Microarrays And Methods Of Use Thereof
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US Patent:

20040253634, Dec 16, 2004
Filed:

May 13, 2004
Appl. No.:

10/474449
Inventors:

Denong Wang - New York NY, US
International Classification:

G01N033/53
C12M001/34
G01N033/543
US Classification:

435/007100, 435/287200, 436/518000
Abstract:

This invention provides novel nitrocellulose-based or llydrogel-based microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, (3) to determine whether a subject is afflicted with a disorder, and (4) to determine whether an agent known to specifically bind to a first compound also specifically binds to a second compound. This invention also provides kits which comprise the instant micoarrays. This invention further provides antibodies capable of specifically binding to a glycomer present both on the surface of a mammalian macrophage or intestinal epithelial cell, and on a bacterial cell. Finally, this invention provides diagnostic methods using the instant antibodies.

Liposome-Based Microarray And Methods Of Use Thereof
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US Patent:

20070059765, Mar 15, 2007
Filed:

Mar 22, 2006
Appl. No.:

11/387993
Inventors:

Denong Wang - Palo Alto CA, US
Leonore Herzenberg - Stanford CA, US
International Classification:

G01N 33/53
C12M 1/34
US Classification:

435007100, 435287200
Abstract:

This invention provides novel liposome-based articles of manufacture and microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, and (3) to determine whether a subject is afflicted with a disorder. This invention also provides kits which comprise the instant microarrays.

Cryptic Glycan Markers And Applications Thereof
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US Patent:

20100178292, Jul 15, 2010
Filed:

Jan 12, 2010
Appl. No.:

12/686102
Inventors:

Denong Wang - Palo Alto CA, US
Thomas Newsom-Davis - Twickenham, GB
Lawrence Steinman - Stanford CA, US
Gavin Screaton - London, GB
Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
Imperial College of London - London
International Classification:

A61K 39/395
C07H 3/06
C07K 16/30
C07K 16/00
C07K 19/00
A61P 35/00
C12N 9/96
C12N 5/00
G01N 33/53
C40B 40/12
C40B 30/04
US Classification:

4241331, 5361231, 5303875, 5303873, 5303913, 4241371, 435188, 435325, 435 721, 506 19, 506 9
Abstract:

The present invention relates to a novel glycan marker of cancer and monoclonal antibodies against it. Furthermore, novel glycan markers and their use in the detection and monitoring of cancerous cells and cancer-associated or specific antibody signatures are described.

Photo-Generated Carbohydrate Arrays And The Rapid Identification Of Pathogen-Specific Antigens And Antibodies
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US Patent:

20100331198, Dec 30, 2010
Filed:

Sep 11, 2007
Appl. No.:

11/900221
Inventors:

Denong Wang - Palo Alto CA, US
Gregory T. Carroll - New York NY, US
Nicholas J. Turro - Tenafly NJ, US
Jeffrey T. Koberstein - Storrs CT, US
International Classification:

C40B 30/04
C40B 40/12
C40B 50/18
US Classification:

506 9, 506 19, 506 32
Abstract:

The invention relates to novel photo-generated carbohydrate arrays and methods of their use to detect the presence of one or more agents in a sample. The invention also relates to a high-throughput strategy to facilitate the identification and immunological characterization of pathogen-specific carbohydrates, including those of . The invention can be used to determine the presence of a pathogen and whether a subject has been exposed to a pathogen, such as by screening for pathogen-specific antibodies.

Glycan Markers And Autoantibody Signatures In Hiv-1 And Hiv-1-Associated Malignancies
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US Patent:

20110177090, Jul 21, 2011
Filed:

Jan 19, 2011
Appl. No.:

13/009474
Inventors:

Denong Wang - Palo Alto CA, US
Leonore A. Herzenberg - Stanford CA, US
Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:

A61K 39/42
C40B 40/12
C40B 30/04
C07K 16/10
C40B 40/10
A61P 31/18
A61P 37/04
US Classification:

4241481, 506 19, 506 9, 53038835, 53038815, 5303873, 506 18
Abstract:

The present invention provides compositions and methods for the specific and sensitive detection and characterization of anti-carbohydrate antibodies against immunogenic sugar moieties on microbes and abnormal cells and anti-HIV-1 protein antibodies for the development of diagnostic, prophylactic and therapeutic strategies against diseases inflicted by cancer cells or microbial pathogens.