Jagabandhu Das - Mercerville NJ Ramesh Padmanabha - Hamden CT Ping Chen - Belle Mead NJ Derek J. Norris - Trenton NJ Arthur M. P. Doweyko - Long Valley NJ Joel C. Barrish - Holland PA John Wityak - Robbinsville NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D27742
US Classification:
514370, 548194
Abstract:
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
Jagabandhu Das - Mercerville NJ, US Ramesh Padmanabha - Hamden CT, US Ping Chen - Belle Mead NJ, US Derek J. Norris - Trenton NJ, US Arthur M. P. Doweyko - Long Valley NJ, US Joel C. Barrish - Holland PA, US John Wityak - Robbinsville NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K031/426 A61K031/44 C07D277/20 C07D417/12
US Classification:
514342, 514371, 5462707, 548195, 544106, 544133
Abstract:
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
Ashvinikumar V. Gavai - Princeton Junction NJ, US Wen-Ching Han - Newtown PA, US Ping Chen - Belle Mead NJ, US Edward H. Ruediger - Greenfield Park, CA Harold Mastalerz - Guilford CT, US Brian E. Fink - Princeton Junction NJ, US Derek J. Norris - Pennington NJ, US
Assignee:
Bristol Myers Squibb Company - Princeton NJ
International Classification:
C07D 487/04 A61K 31/53 A61P 19/02
US Classification:
544183, 514243
Abstract:
The present invention provides compounds of formula IThe compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
Jagabandhu Das - Mercerville NJ, US Ramesh Padmanabha - Hamden CT, US Ping Chen - Belle Mead NJ, US Derek J. Norris - Trenton NJ, US Arthur M. P. Doweyko - Long Valley NJ, US Joel C. Barrish - Holland PA, US John Wityak - Robbinsville NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/4439 C07D 417/12
US Classification:
514342, 5462707
Abstract:
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
Shankar Swaminathan - Monmouth Junction NJ, US Ashvinikumar V. Gavai - Princeton Junction NJ, US Junying Fan - Monmouth Junction NJ, US Bharat P. Patel - Pennington NJ, US Derek J. Norris - Pennington NJ, US Richard Michael Corbett - Robbinsville NJ, US Bin Zheng - Kendall Park NJ, US
The present invention provides a process for preparing compounds of formula (I)The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
Jagabandhu Das - Mercerville NJ, US Ramesh Padmanabha - Hamden CT, US Ping Chen - Belle Mead NJ, US Derek J. Norris - Trenton NJ, US Arthur M. P. Doweyko - Long Valley NJ, US Joel C. Barrish - Richboro PA, US John Wityak - Robbinsville NJ, US Louis J. Lombardo - Belle Mead NJ, US Francis Y. F. Lee - Yardley PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/427 A61K 31/496 A61K 31/501
US Classification:
51425219, 514370
Abstract:
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
Brian E. Fink - Princeton Junction NJ, US Ashvinikumar V. Gavai - Princeton Junction NJ, US Gregory D. Vite - Titusville NJ, US Ping Chen - Belle Mead NJ, US Harold Mastalerz - Guilford CT, US Derek J. Norris - Pennington NJ, US John S. Tokarski - Princeton NJ, US Yufen Zhao - Pennington NJ, US Wen-Ching Han - Newton PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 487/04 A61K 31/53
US Classification:
514243, 544183
Abstract:
The present invention provides compounds of formula IThe formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
Joel C. Barrish - Richboro PA, US John Wityak - Carlsbad CA, US Jagabandhu Das - Mercerville NJ, US Ping Chen - Belle Mead NJ, US Derek J. Norris - Pennington NJ, US Gary Schieven - Lawrenceville NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/497 C07D 241/02
US Classification:
51425211, 544357
Abstract:
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
ed accounts that culminated in a 40-game suspension. Back in 2017, free-agent catcher Derek Norris was suspended for the final month of the season under similar circumstances, when his ex-fiancee alleged both physical and emotional abuse in an Instagram post that also declined to mention him by name.
Date: Nov 26, 2019
Category: Sports
Source: Google
Gamel out, Mariners thin in outfield, Ichiro could return
ork starter Matt Harvey threw three shutout innings, allowing two hits. Brandon Nimmo hit a leadoff home run, his second of the spring. Detroit starter Mike Fiers worked 2 1/3 innings, giving up two runs and two hits. Derek Norris doubled and singled, raising his batting average this spring to .556.
Hahn, 28, had fallen out of favor with the As the past two years after numerous injuries, and he spent much of his time at Triple-A Nashville. Acquired from San Diego in the Derek Norris deal after the 2014 season, he went 3-6 with a 5.30 ERA in 14 games, 13 starts, last year.
Date: Jan 29, 2018
Category: Sports
Source: Google
Rays hold team meeting to talk about defense, then get routed by Tigers (w/video)
There aren't many positions where the Rays can, or would want to, make a change. They are going to start playing Jesus Sucre more instead of Derek Norris at catcher, in advance of Wilson Ramos returning.
Date: Jun 16, 2017
Category: Sports
Source: Google
Russell Martin's homer the difference as Blue Jays edge Rays
Pillar reached on a leadoff walk, stole second and moved to third on catcher Derek Norriss wide throw. After Bautista walked, Pillar scored when Morales beat out a potential double-play ball at first base.
Date: Jun 14, 2017
Source: Google
Addison Russell, Cubs issue statements as MLB looks into domestic abuse allegations
MLB also is currently investigating an allegation against Rays catcher Derek Norris, whose former fiancee claimed he physically and emotionally abused her. Norris agent issued a statement from Norris to the Tampa Bay Times saying: I have NEVER been physically or emotionally abusive towards her,
Date: Jun 08, 2017
Category: Sports
Source: Google
Twins eventually cash in as Rays lose, fall back to .500 (w/video)
walked then, after Kevin Kiermaier struck out, loaded the bases when Rickie Weeks also walked against Twins lefty Adalberto Mejia. Derek Norris' single scored one, but that was it as Souza got thrown out trying to score on an errant pitch and Peter Bourjos grounded out. In review, a double, single,
Date: May 27, 2017
Category: Sports
Source: Google
Joe Girardi is helping Yankees bullpen get exposed
The bullpen allowed eight baserunners Friday, and when Yankees-killer Evan Longoria lashed a single to left in the eighth to score Derek Norris with the go-ahead run, it spelled doom for Yankees and pitcher Tyler Clippard, who walked two batters in the inning to set up the run.
Derek Norris (1985-1991), Ann Smith (1958-1966), Stacy Shaw (1982-1982), Brittany Pettis (1993-1996), Ronald Beatty (1960-1965), Chad Ettore (1986-1991)