Devin B Lowe

US Patent:

20140314758, Oct 23, 2014

Filed:

Nov 15, 2012

Appl. No.:

14/358705

Inventors:

- Pittsburgh PA, US
Anamika Bose - Kolkata, IN
Jennifer Lynn Taylor - McDonald PA, US
Xi Zhao - Pittsburgh PA, US
Devin B. Lowe - Pittsburgh PA, US

Assignee:

University of Pittsburgh- Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61K 39/00
A61K 31/506
A61K 45/06

US Classification:

4241331, 530328, 530322, 4241851, 536 235, 4353201, 435325, 435366, 43525233, 435365, 435362, 435367, 435373

Abstract:

Immunogenic peptides from tumor associated stromal cell antigens, including combinations of such peptides, are disclosed herein. In some examples the peptides are useful for methods of eliciting an immune response. In additional examples the peptides are useful for methods of treating cancer. Methods for decreasing vascularization of a tumor using a Protein Delta Homolog 1 (DLK1) protein or a nucleic acid encoding the protein are also disclosed.