Diana I Brixner

US Patent:

50667890, Nov 19, 1991

Filed:

Sep 29, 1989

Appl. No.:

7/415154

Inventors:

Ananthachari Srinivasan - Kirkland WA
Diana I. Brixner - Lynnwood WA
Vivekananda M. Vrudhula - Edmonds WA

Assignee:

NeoRx Corporation - Seattle WA

International Classification:

C07K 1528

US Classification:

530388

Abstract:

Targeting substance-diagnostic/therapeutic agent conjugates joined by stabilized Schiff base or hydrazone linkages are disclosed. In addition, slow release carrier-drug pharmaceuticals are described. The diagnostic and therapeutic conjugates and pharmaceuticals of the present invention provide certain advantages relating to in vivo administration, including controlled release of the active agent at a target site.

US Patent:

50948482, Mar 10, 1992

Filed:

Jun 30, 1989

Appl. No.:

7/373426

Inventors:

Diana I. Brixner - Lynnwood WA

Assignee:

Neorx Corporation - Seattle WA

International Classification:

A61K 3944
C07K 1710
C07K 1706

US Classification:

424 8591

Abstract:

The specificity of a pharmaceutical agent for a given site of action is increased by covalently bonding the agent via a diphosphate or amidated diphosphate bond to a targeting moiety, preferably a polypeptide specific for the site.

US Patent:

55498833, Aug 27, 1996

Filed:

Jun 3, 1993

Appl. No.:

8/071357

Inventors:

Ananthachari Srinivasan - St. Charles MO
Vivekananda M. Vrudhula - Edmonds WA
Diana I. Brixner - Lynnwood WA

Assignee:

NeoRx Corporation - Seattle WA

International Classification:

A61K 5108
A61K 4900
C07K 100
C07K 200

US Classification:

424 145

Abstract:

A chemically defined polymeric carrier comprising a series of. alpha. -amino acids in any combination containing side chains to which diagnostic/therapeutic and chelating agents can be covalently joined through cleavable linkers either directly or covalently joined through cleavable linkers after chemical modification of the side chains. Hydrazone, disulfide, and ester linkages in any combination can be present in the polymeric carrier between the side chains of the. alpha. -amino acids and the agents. The presence of a particular covalent linkage between the side chain and the agent in the carrier is determined by the functional group present in the side chain of the. alpha. -amino acid and the functional group present in the agent. The. alpha. -amino acids with side chains to which agents do not covalently join can function as spacers to minimize interaction between bulky molecules attached to the polymeric carrier. In addition, those. alpha.