Diana M Maul

US Patent:

54686067, Nov 21, 1995

Filed:

Jul 31, 1992

Appl. No.:

7/923304

Inventors:

Gregory R. Bogart - Fort Collins CO
Garret R. Moddel - Boulder CO
Diana M. Maul - Thornton CO
Jeffrey B. Etter - Boulder CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33543
G01N 33545
G01N 33551
G01N 33552

US Classification:

435 5

Abstract:

Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in any amount selected from 0. 1 nM, 0. 1 ng/ml, 50 fg, and 2. times. 10. sup. 3 organisms comprising the analyte.

US Patent:

59553774, Sep 21, 1999

Filed:

Apr 17, 1995

Appl. No.:

8/403565

Inventors:

Diana M. Maul - Thornton CO
Gregory R. Bogart - Fort Collins CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33543
G01N 33547

US Classification:

436518

Abstract:

Method for detecting an analyte of interest, comprising the steps of providing a detection device comprising a light reflective or transmissive substrate supporting one or more layers comprising an adhering attachment layer to which is affixed a receptive material which specifically interacts with the analyte of interest; reacting the device with a sample potentially comprising the analyte under conditions in which the analyte binds to the receptive material; and reacting bound analyte with a reagent which creates a mass change on the surface of the device.

US Patent:

54828309, Jan 9, 1996

Filed:

Jun 10, 1993

Appl. No.:

8/076320

Inventors:

Gregory R. Bogart - Berthoud CO
Garret R. Moddel - Boulder CO
Diana M. Maul - Thornton CO
Jeffrey B. Etter - Boulder CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33544
C12Q 100

US Classification:

435 5

Abstract:

Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface of any amount selected from 0. 1 nM, 0. 1 ng/ml, 50 fg, and 2. times. 10. sup. 3 organisms comprising the analyte.

US Patent:

54948290, Feb 27, 1996

Filed:

Jun 10, 1993

Appl. No.:

8/075128

Inventors:

Torbjorn Sandstrom - Molnlycke, SE
Lars Stiblert - Gothengurg, SE
Diana M. Maul - Thornton CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33543
G01N331;551

US Classification:

436518

Abstract:

Instrument configured and arranged to detect the presence or amount of an analyte of interest on the substrate of an optical device. The instrument has a source of linearly polarized, monochromatic light positioned at an angle other than Brewster's angle relative to the substrate; and an analyzer positioned at the same angle relative to the substrate at a location suitable for detecting reflected polarized light from the substrate; wherein the analyzer is configured and arranged to approximately maximize the change in intensity of the light reflected from the substrate that is transmitted through the analyzer when a change in mass occurs at the substrate relative to an unreacted surface.

US Patent:

54181364, May 23, 1995

Filed:

Jun 10, 1993

Appl. No.:

8/076719

Inventors:

B. John Miller - Boulder CO
Diana M. Maul - Thornton CO
James Blessing - Boulder CO
Mark Crosby - Niwot CO
Howard Kelley - Boulder CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33543
G01N 33544
G01N 33552
G01N 33569

US Classification:

435 5

Abstract:

Optical assay device having an active receptive surface supported on a pedestal and held within a first container; the first container comprising first absorbent material located at the base of the pedestal, configured and arranged to absorb liquid draining from the surface, and having a second container, hingedly connected to one side of the first container, the second container comprising a second absorbent material, wherein the second container can be closed to the first container by rotation about the hinge, and wherein such closing causes the second absorbent material to contact the surface.

US Patent:

56311710, May 20, 1997

Filed:

May 31, 1995

Appl. No.:

8/455493

Inventors:

Torbjorn Sandstrom - Molnlycke, SE
Lars Stiblert - G oteborg, SE
Diana M. Maul - Thornton CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33543
G01N 33552

US Classification:

436518

Abstract:

An instrument configured and arranged to detect a change in thickness or refractive index of a thin film substrate. A method for optimizing the instrument and a method for detecting a change in thickness or refractive index of a thin film substrate.

US Patent:

55410570, Jul 30, 1996

Filed:

Jun 10, 1993

Appl. No.:

8/075952

Inventors:

Gregory R. Bogart - Berthoud CO
Garret R. Moddel - Boulder CO
Diana M. Maul - Thornton CO
Jeffrey B. Etter - Boulder CO
Mark Crosby - Niwot CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

C12Q 170
G01N 3353
G01N 33543
G01N 2100

US Classification:

435 5

Abstract:

Method for detecting the presence or amount of an analyte of interest in a sample by providing a substrate having an optically active surface exhibiting a first color in response to light impinging thereon, and exhibiting a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in an amount selected from any one of 0. 1 nM, 0. 1 ng/ml, 50 fg, 2. times. 10. sup. 3 organisms comprising the analyte; and contacting the optically active surface with a sample potentially comprising the analyte of interest under conditions in which the analyte can interact with the optically active surface to cause the optically active surface to exhibit the second color when the analyte is present.

US Patent:

58692720, Feb 9, 1999

Filed:

May 31, 1995

Appl. No.:

8/455652

Inventors:

Gregory R. Bogart - Berthoud CO
Garret R. Moddel - Boulder CO
Diana M. Maul - Thornton CO
Jeffrey B. Etter - Boulder CO
Mark Crosby - Niwot CO

Assignee:

Biostar, Inc. - Boulder CO

International Classification:

G01N 33551
G01N 33552
G01N 33569

US Classification:

435 732

Abstract:

Method for the determination of chlamydial or gram negative bacterial antigen comprising contacting a sample potentially containing extracted antigen with an optically active surface comprising an attachment layer, and a layer of non-specific protein.