Diane Lynn Mccarthy

US Patent:

20150083906, Mar 26, 2015

Filed:

Apr 16, 2013

Appl. No.:

14/394872

Inventors:

- Rahway NJ, US
Sandra C. Souza - Jersey City NJ, US
Hidehisa Asada - Washington Township NJ, US
Yoshiaki Miura - Glen Rock NJ, US
Taku Nakahara - West New York NJ, US
Diane McCarthy - Warrington PA, US

International Classification:

G01N 33/96
H01J 49/16
H01J 49/34

US Classification:

250282

Abstract:

The use of N-linked glycosylation pattern of serum proteins as a biomarker for evaluating the efficacy of intervention therapies for diabetes is disclosed. As disclosed herein, changes in the N-linked glycosylation of total plasma proteins precedes and predicts the decrease in glycated hemoglobin (HbA1c) associated with successful treatment of diabetes. Therefore, measuring changes in N-linked glycosylation of total serum plasma proteins over time may be used as a biomarker to evaluate or access the efficacy of an intervention therapy for diabetes.

US Patent:

20150072888, Mar 12, 2015

Filed:

Apr 19, 2013

Appl. No.:

14/395149

Inventors:

- Tokyo, JP
Diane McCarthy - Warrington PA, US
Yoshiaki Miura - Glen Rock NJ, US
Taku Nakahara - West New York NJ, US

International Classification:

G01N 33/66

US Classification:

506 9, 435 14, 436501, 436 94, 436 95, 5361231, 422430, 435 792, 506 12, 506 19

Abstract:

The present invention relates to the use of N-linked glycan profiles of blood or blood component proteins as biomarkers for diagnosing diabetes mellitus and for monitoring the efficacy of anti-diabetic therapy. Specifically, the present invention relates to detecting changes in the amounts of N-linked glycans as diagnostic biomarkers for diabetes mellitus and as indicators of the efficacy of anti-diabetic therapy over time.