Diane E Sutter

US Patent:

7083592, Aug 1, 2006

Filed:

Sep 27, 2004

Appl. No.:

10/951217

Inventors:

Alexander G. Lastovich - Raleigh NC, US
James K. Fentress - Morrisville NC, US
Julia Griggs - Oakland NJ, US
Ronald J. Pettis - Cary NC, US
Diane Sutter - Cary NC, US
Frank E. Martin - Durham NC, US
M. Ishaq Haider - Morrisville NC, US

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

A61B 17/20

US Classification:

604 47

Abstract:

An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.

US Patent:

20030220610, Nov 27, 2003

Filed:

Feb 4, 2003

Appl. No.:

10/357502

Inventors:

Alexander Lastovich - Raleigh NC, US
James Fentress - Morrisville NC, US
Julia Griggs - Morrisville NC, US
Ronald Pettis - Cary NC, US
Diane Sutter - Cary NC, US
Frank Martin - Durham NC, US
M. Haider - Morrisville NC, US

Assignee:

Becton Dickinson and Company

International Classification:

A61M037/00

US Classification:

604/047000

Abstract:

An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.

US Patent:

20050038378, Feb 17, 2005

Filed:

Sep 27, 2004

Appl. No.:

10/951208

Inventors:

Alexander Lastovich - Raleigh NC, US
James Fentress - Morrisville NC, US
Julia Griggs - Oakland NJ, US
Ronald Pettis - Cary NC, US
Diane Sutter - Cary NC, US
Frank Martin - Durham NC, US
M. Haider - Morrisville NC, US

Assignee:

Becton, Dickinson and Company - Frank Lakes NJ

International Classification:

A61M035/00
A61B017/20

US Classification:

604047000, 604001000

Abstract:

An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.

US Patent:

20050124967, Jun 9, 2005

Filed:

Dec 28, 2001

Appl. No.:

10/487485

Inventors:

Scott Kaestner - Durham NC, US
Ronald Pettis - Cary NC, US
Diane Sutter - Cary NC, US
John Mikszta - Durham NC, US

International Classification:

A61M031/00

US Classification:

604506000, 604522000

Abstract:

A method and device for administration of a high molecular weight protein into the intradermal space.

US Patent:

20050163711, Jul 28, 2005

Filed:

Jun 14, 2004

Appl. No.:

10/867908

Inventors:

Colleen Nycz - Raleigh NC, US
Glenn Vonk - Fuquay Varina NC, US
John Brittingham - Wake Forest NC, US
Ronald Pettis - Cary NC, US
Alfred Harvey - Durham NC, US
Robert Campbell - Bahama NC, US
John Mikszta - Durham NC, US
Diane Sutter - Cary NC, US

International Classification:

A61K049/00

US Classification:

424009100

Abstract:

The present invention relates to methods and devices for delivering one or more biologically active agents, particularly a diagnostic agent to the intradermal compartment of a subject's skin. The present invention provides an improved method of delivery of biologically active agents in that it provides among other benefits, rapid uptake into the local lymphatics, improved targeting to a particular tissue, improved bioavailability, improved tissue bioavailability, improved tissue specific kinetics, improved deposition of a pre-selected volume of the agent to be administered, and rapid biological and pharmacodynamics and biological and pharmacokinetics. This invention provides methods for rapid transport of agents through lymphatic vasculature accessed by intradermal delivery of the agent. Methods of the invention are particularly useful for delivery of diagnostic agents.

US Patent:

20050203000, Sep 15, 2005

Filed:

Mar 26, 2004

Appl. No.:

10/809930

Inventors:

Diane Sutter - Cary NC, US
Ronald Pettis - Cary NC, US
Scott Kaestner - Durham NC, US

International Classification:

A61K038/28
A61K031/727
A61K031/415
A61K031/192
A61K031/045

US Classification:

514003000, 514728000, 514690000, 514569000, 514406000, 514056000

Abstract:

Formulations and methods for reducing pain during intradermal injection, in particular the use of benzyl alcohol, phenolic agents and aromatic preservatives, antimicrobials and antioxidants for such formulations and methods.

US Patent:

20050245594, Nov 3, 2005

Filed:

May 11, 2005

Appl. No.:

11/126332

Inventors:

Diane Sutter - Cary NC, US
Scott Kaestner - Durham NC, US
Ronald Pettis - Cary NC, US

International Classification:

A61K031/405

US Classification:

514419000

Abstract:

The present invention relates to methods and devices for delivery of therapeutically and/or prophylactically effective amounts of agents for management of pain, particularly anti-migraine agents, more particularly triptan compounds, by depositing the agent into the intradermal or junctional compartment of a subject's skin. Agents delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods, including intraperitoneal, intramuscular and subcutaneous delivery. The methods of the present invention provide benefits and improvements over conventional drug delivery methods including dose sparing, increased drug efficacy, reduced side effects.

US Patent:

20050256182, Nov 17, 2005

Filed:

May 11, 2005

Appl. No.:

11/126335

Inventors:

Diane Sutter - Cary NC, US
Scott Kaestner - Durham NC, US
Ronald Pettis - Cary NC, US

International Classification:

A61K031/405

US Classification:

514419000

Abstract:

The present invention relates to novel anti-pain formulations and methods of their delivery. Anti-pain agents delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods, including oral, intramuscular and subcutaneous delivery. The methods of the present invention provide benefits and improvements over conventional drug delivery methods including dose sparing, increased drug efficacy, reduced side effects.