Dianna M Milewicz

US Patent:

20110028331, Feb 3, 2011

Filed:

Sep 24, 2008

Appl. No.:

12/679770

Inventors:

Dianna M. Milewicz - Houston TX, US
Dongchuan Guo - Pearland TX, US
Hariyadarshi Pannu - Houston TX, US
Van Tran Fadulu - Manvel TX, US

Assignee:

BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

C40B 30/00

US Classification:

506 7

Abstract:

A method of detecting in an individual an increased risk of hyperplastic vasculomyopathy, or a vascular disease resulting therefrom is disclosed. The method comprises obtaining a DNA genome sample from the individual and detecting in the sample a missense mutation in a gene which is a component of a smooth muscle cell contractile unit. In some embodiments the gene is ACTA2 and in some embodiments the gene is MYH11. In some embodiments, the gene is sequenced and then compared to a panel of control gene sequences which are representative of the same gene in individuals without vascular disease or who are at low risk of developing hyperplastic vasculomyopathy, to detect any missense mutations in the gene. The presence of a missense mutation in the gene indicates an increased risk of hyperplastic vasculomyopathy.

US Patent:

20080305498, Dec 11, 2008

Filed:

Oct 14, 2005

Appl. No.:

11/577287

Inventors:

Dianna M. Milewicz - Houston TX, US
William P. Dubinsky - Houston TX, US

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS - AUSTIN TX

International Classification:

G01N 33/554
C12Q 1/02

US Classification:

435 721, 435 29

Abstract:

The present invention relate to a method of diagnosing a subject having a vessel disorder. More particularly, a biological sample is obtained from a subject suspected of having a vessel disorder. A protein profile is determined or measured in the sample using procedures described herein, for example, mass spectrometry or immunodetection. The protein profile from the subject is compared to a protein profile in a healthy control, wherein an alteration in the levels of a protein of the profile in the subject compared to the healthy control is indicative of a vessel disorder.