Dianne M Fishwild

US Patent:

7084260, Aug 1, 2006

Filed:

Oct 10, 1996

Appl. No.:

08/728463

Inventors:

Nils Lonberg - Woodside CA, US
Robert M. Kay - San Francisco CA, US
Dianne M. Fishwild - Mountain View CA, US

Assignee:

GenPharm International, Inc. - Milpitas CA

International Classification:

C07K 16/00

US Classification:

53038875, 5303873, 5303881

Abstract:

The invention relates to transgenic non-human animals capable of producing high affinity human sequence antibodies. The invention is also directed to human sequence antibodies specific for human antigens, such as, human CD4. The invention also is directed to methods for producing human sequence antibodies.

US Patent:

7722873, May 25, 2010

Filed:

Feb 8, 2006

Appl. No.:

11/349724

Inventors:

Nils Lonberg - Woodside CA, US
Robert M. Kay - San Francisco CA, US
Dianne M. Fishwild - Mountain View CA, US

Assignee:

Genpharm International, Inc. - Palo Alto CA

International Classification:

A61K 39/395

US Classification:

4241421, 4241431, 4241811, 435 696, 53038815, 53038822

Abstract:

The invention relates to transgenic non-human animals capable of producing high affinity human sequence antibodies. The invention is also directed to human sequence antibodies specific for human antigens, such as, human CD4. The invention also is directed to methods for producing human sequence antibodies.

US Patent:

8231877, Jul 31, 2012

Filed:

Apr 29, 2010

Appl. No.:

12/770402

Inventors:

Nils Lonberg - Woodside CA, US
Robert M. Kay - San Francisco CA, US
Dianne M. Fishwild - Mountain View CA, US

Assignee:

GenPharm International, Inc. - Milpitas CA

International Classification:

A61K 39/395

US Classification:

4241541, 4241811

Abstract:

The invention relates to transgenic non-human animals capable of producing high affinity human sequence antibodies. The invention is also directed to human sequence antibodies specific for human antigens , such as, human CD4. The invention also is directed to methods for producing human sequence antibodies.

US Patent:

20090220989, Sep 3, 2009

Filed:

Dec 5, 2006

Appl. No.:

12/096342

Inventors:

Kamala Tyagarajan - Fremont CA, US
Dianne M. Fishwild - Mountain View CA, US
David A. King - Menlo Park CA, US

Assignee:

GUAVA TECHNOLOGIES - Hayward CA

International Classification:

G01N 33/53
C12M 1/34

US Classification:

435 72, 436501, 4352887

Abstract:

Methods for assaying a sample for an analyte are provided. In various embodiments, the methods comprise contacting a sample suspected of containing the analyte with a non-uniform particle comprising a capture molecule, and further contacting the particle with a detection moiety comprising a label that permits detection of the analyte when associated with the particle. The methods may be performed to detect and/or quantitate analyte in the sample. In some embodiments, the methods may be performed in an automated manner, and may use an optical and/or cytometric apparatus for performing the method(s). The methods may further be performed with automated vessel-processing apparatus(es), such as plate loaders, plate washers, etc. Also provided are complexes containing the described materials formed by an assay of the invention, including excited state complexes. Kits useful for performing such methods are also provided.

US Patent:

20130039850, Feb 14, 2013

Filed:

Jul 9, 2012

Appl. No.:

13/544012

Inventors:

Nils LONBERG - Woodside CA, US
Robert M. KAY - San Francisco CA, US
Dianne M. FISHWILD - Mountain View CA, US

Assignee:

GENPHARM INTERNATIONAL, INC. - Milpitas CA

International Classification:

C12N 15/13
C12P 21/08
A61K 39/395
A61K 51/10
G01N 33/577
A61P 19/02
C12N 5/10
A61P 37/06
A61P 29/00
A61P 9/00
A61P 31/00
A61P 7/00
C12N 15/63
C12N 5/16

US Classification:

424 149, 536 2353, 4353201, 435 7021, 4241441, 4241351, 4241781, 435 724, 435334

Abstract:

The invention relates to transgenic non-human animals capable of producing high affinity human sequence antibodies. The invention is also directed to human sequence antibodies specific for human antigens, such as, human CD4. The invention is also directed to methods for producing human sequence antibodies.

US Patent:

57668868, Jun 16, 1998

Filed:

Aug 13, 1993

Appl. No.:

8/107669

Inventors:

Gary M. Studnicka - Santa Monica CA
Roger G. Little - Benicia CA
Dianne M. Fishwild - Hayward CA
Fred R. Kohn - Walnut Creek CA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

C12P 2104
C12N 1500
C07K 1600
A61K 39395

US Classification:

435 7021

Abstract:

Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a heterologous species and for preparing so modified antibody variable domains which are useful for administration to heterologous species. Antibody variable regions prepared by the methods of the invention are also described.