Donald J Buchsbaum from Miramar Beach, FL, age 80

Name / Title

Company / Classification

Phones & Addresses

Donald J. Buchsbaum
Principal

Cdept
Commercial Physical Research

140 Windwood Cir, Alabaster, AL 35007

Donald J Buchsbaum

CDEPT, LLC
INEST/HOLD/DEVELOP INTELLECTUAL PROPERTY

Alabaster, AL

Us Patents

Enhancement Of Tumor Cell Chemosensitivity And Radiosensitivity Using Single Chain Secretory Antibodies
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US Patent:

6468547, Oct 22, 2002
Filed:

Feb 7, 2000
Appl. No.:

09/499543
Inventors:

Donald J. Buchsbaum - Birmingham AL
David T. Curiel - Birmingham AL
Murray Stackhouse - Helena AL
Assignee:

UAB Research Foundation - Birmingham AL
International Classification:

A61K 3900
US Classification:

4242771, 4241301, 4241331, 4241351, 4241381, 4241411, 5303871, 5303873, 5303877
Abstract:

The present invention provides a method of enhancing the chemosensitivity and radiosensitivity of a neoplastic cell expressing an oncoprotein that stimulates proliferation of the cell, comprising introducing into the cell a nucleic acid molecule encoding an antibody homologue, wherein the antibody homologue is expressed intracellularly and binds to the oncoprotein intracellularly in the endoplasmic reticulum of the cell. The present invention is also directed to a method for enhancing the inhibition of proliferation of a neoplastic cell expressing an oncoprotein that stimulates proliferation of the cell, comprising the steps of: introducing into the cell a nucleic acid molecule encoding an antibody homologue, wherein the antibody homologue is expressed intracellularly and binds to the protein intracellularly; and contacting said cell with an anti-neoplastic agent.

Molecular Chemotherapy Enhancement Of Radiotherapy
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US Patent:

6599909, Jul 29, 2003
Filed:

Sep 29, 1999
Appl. No.:

09/408055
Inventors:

Donald J. Buchsbaum - Birmingham AL
David T. Curiel - Birmingham AL
Murray A. Stackhouse - Birmingham AL
Lee C. Pederson - Birmingham AL
Assignee:

UAB Research Foundation - Birmingham AL
International Classification:

A61K 31505
US Classification:

514274, 424 9321
Abstract:

The present invention provides a new approach for cancer treatment by utilizing gene therapy combined with radiation therapy to enhance cytotoxicity in malignant cells. Specifically, the present invention demonstrates that molecular chemotherapy with the cytosine deaminase gene and 5-fluorocytosine is an effective radiosensitizing strategy which may lead to substantial improvement in tumor control, with less normal tissue toxicity than conventional systemic administration of 5-fluorouracil, that would translate into improved cure rates and better survival. Also provided is a noninvasive method for continuous in vivo monitoring of 5-fluorouracil production via magnetic resonance spectroscopy.

Combinations Of Dr5 Antibodies And Other Therapeutic Agents
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US Patent:

7279160, Oct 9, 2007
Filed:

Oct 25, 2002
Appl. No.:

10/281479
Inventors:

Tong Zhou - Birmingham AL, US
Kimihisa Ichikawa - Kanagawa-Ken, JP
Robert P. Kimberly - Birmingham AL, US
William J. Koopman - Indian Springs AL, US
Jun Ohsumi - Kanagawa-ken, JP
Albert F. Lobuglio - Birmingham AL, US
Donald J. Buchsbaum - Alabaster AL, US
Assignee:

The UAB Research Foundation - Birmingham AL
International Classification:

C07K 16/28
C07K 16/30
A61K 39/395
US Classification:

4241431, 4241381, 5303871, 53038822, 5303888, 530350, 53038885
Abstract:

An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.

Antibody Selective For Dr4 And Uses Thereof
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US Patent:

7476383, Jan 13, 2009
Filed:

Oct 31, 2002
Appl. No.:

10/286132
Inventors:

Tong Zhou - Birmingham AL, US
Robert P. Kimberly - Birmingham AL, US
William J. Koopman - Indian Springs AL, US
Albert F. Lobuglio - Birmingham AL, US
Donald J. Buchsbaum - Montevallo AL, US
Assignee:

The UAB Research Foundation - Birmingham AL
International Classification:

C07K 16/28
C07K 16/30
A61K 39/395
US Classification:

4241431, 4241381, 5303871, 53038822, 5303888, 530350, 5303873, 435334, 435344
Abstract:

An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of DR5 and DR4 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.

Combinations Of Antibodies Selective For Dr5 And Other Therapeutic Agents
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US Patent:

7704502, Apr 27, 2010
Filed:

May 22, 2007
Appl. No.:

11/752153
Inventors:

Tong Zhou - Birmingham AL, US
Kimihisa Ichikawa - Kanagawa-ken, JP
Robert P. Kimberly - Birmingham AL, US
William J. Koopman - Indian Springs AL, US
Jun Ohsumi - Kanagawa-ken, JP
Albert F. LoBuglio - Birmingham AL, US
Donald J. Buchsbaum - Alabaster AL, US
Assignee:

The UAB Research Foundation - Birmingham AL
International Classification:

A61K 39/395
C07K 16/28
C07K 16/30
US Classification:

4241431, 4241381, 5303871, 53038822, 5303888, 530350, 53038885
Abstract:

An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.

Combinations Of Antibodies Selective For Dr5 And Other Therapeutic Agents
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US Patent:

7981421, Jul 19, 2011
Filed:

Jan 13, 2010
Appl. No.:

12/686659
Inventors:

Tong Zhou - Birmingham AL, US
Kimihisa Ichikawa - Kanagawa-ken, JP
Robert P. Kimberly - Birmingham AL, US
William J. Koopman - Indian Springs AL, US
Jun Ohsumi - Kanagawa-ken, JP
Albert F. LoBuglio - Birmingham AL, US
Donald J. Buchsbaum - Alabaster AL, US
Assignee:

The UAB Research Foundation - Birmingham AL
International Classification:

A61K 39/395
C07K 16/28
C07K 16/30
US Classification:

4241431, 4241381, 4241331, 4241551, 4241351, 5303871, 53038822, 5303888, 530350, 5303877, 5303873, 514 11, 514 89, 514 189, 514 193, 514 212
Abstract:

An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.

Radiolabeled Immunotoxins
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US Patent:

20020048550, Apr 25, 2002
Filed:

Jul 20, 2001
Appl. No.:

09/910639
Inventors:

Daniel Vallera - St. Louis Park MN, US
Donald Buchsbaum - Birmingham AL, US
International Classification:

A61K051/00
C12N009/22
C07K014/415
C07K014/24
C07K014/00
US Classification:

424/001690, 424/001570, 530/350000, 435/199000, 530/370000
Abstract:

The invention features radiolabeled immunotoxins, and radiolabeled multimeric (e.g., dimeric) immunotoxins. Also encompassed by the invention are methods of killing pathogenic cells, imaging, and making radiolabeled immunotoxins and radiolabeled multimeric immunotoxins.

Combination Radiation Therapy And Chemotherapy In Conjunction With Administration Of Growth Factor Receptor Antibody
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US Patent:

20020076408, Jun 20, 2002
Filed:

Dec 7, 2001
Appl. No.:

10/004833
Inventors:

Donald Buchsbaum - Birmingham AL, US
International Classification:

A61K039/395
A61K031/704
A61K033/24
A61K031/4745
A61K031/337
US Classification:

424/143100, 514/034000, 424/649000, 514/050000, 514/449000, 514/283000
Abstract:

This invention comprises a method of inhibiting tumor growth in tumors having growth factor receptors comprising administering, about simultaneously, antibodies to the target growth factor receptors, at least one chemotherapeutic agent and radiation therapy.