Donald W Combs

US Patent:

6555536, Apr 29, 2003

Filed:

May 11, 2001

Appl. No.:

09/854302

Inventors:

Thomas P. Burris - Noblesville IN
Donald W. Combs - Neptune City NJ
Philip J. Rybczynski - Branchburg NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 315377

US Classification:

5142305, 514 80, 544105

Abstract:

The invention is directed to 4h-benzo[1,4]oxazin-3-ones useful as peroxisome proliferator activated receptor gamma (PPAR) agonists or antagonists. Pharmaceutical compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.

US Patent:

6908908, Jun 21, 2005

Filed:

Nov 21, 2001

Appl. No.:

09/990461

Inventors:

Thomas P. Burris - Noblesville IN, US
Donald W. Combs - Neptune City NJ, US
Philip J. Rybczynski - Branchburg NJ, US
Joseph Dudash, Jr. - Hillsborough NJ, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K031/538
C07D265/36

US Classification:

514 80, 5142305, 544105

Abstract:

The invention is directed to 4h-benzo[1,4]oxazin-3-ones useful as peroxisome proliferator activated receptor gamma (PPARγ) agonists or antagonists. Pharmaceutical compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.

US Patent:

7071333, Jul 4, 2006

Filed:

Jul 29, 2004

Appl. No.:

10/901677

Inventors:

Donald Combs - Neptune City NJ, US
Charles M. Langevine - Brooklyn NY, US
Yuping Qiu - Glastonbury CT, US
Fred Christopher Zusi - Hamden CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/14
A61K 31/519
A61P 11/06
A61P 19/02

US Classification:

544251, 514267

Abstract:

The present invention provides for triazolopurine-based tricyclic compounds having the formula (I),.

US Patent:

56841515, Nov 4, 1997

Filed:

Mar 6, 1995

Appl. No.:

8/362476

Inventors:

Donald W. Combs - Piscataway NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

C07D23704
C07D40904
C07D23726

US Classification:

544224

Abstract:

Disclosed are progestin agonists having the following formula: ##STR1## W is absent or --CH. dbd. CH--; R. sup. 1 are independently selected from the group consisting of halogen, --CF. sub. 3, and NO. sub. 2, or both R. sup. 1 may be joined to form a bi-radical which is --CH. dbd. CHCH. dbd. CH--; R. sup. 3 are independently selected from the group consisting of hydrogen, C. sub. 1-6 branched or linear alkyl, halogen and --CF. sub. 3, with the proviso that R. sup. 3 at the 3-position must be H where R. sup. 3 at the 4-position is H, or both R. sup. 3 may be joined to form a bi-radical selected from the group consisting of --CH. dbd. CHCH. dbd. CH--, --C(NC. sub. 1-4 alkyl. sub. 2)=CHCH. dbd. CH-- and --(CH. sub. 2). sub. 4 --; R. sup.

US Patent:

53267656, Jul 5, 1994

Filed:

Nov 6, 1991

Appl. No.:

7/789379

Inventors:

Donald W. Combs - Piscataway NJ
Robert Falotico - Belle Mead NJ
Victor Bandurco - Bridgewater NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 31505
C07D40304

US Classification:

514259

Abstract:

Novel 2,2,4-trialkyl-1,2-dihydroquinazoline-3-oxides and their synthesis are described. These compounds possess cardiotonic activity, and are useful for the treatment of heart failure.

US Patent:

50306359, Jul 9, 1991

Filed:

Aug 8, 1990

Appl. No.:

7/564906

Inventors:

Donald W. Combs - Piscataway NJ
Robert Falotico - Belle Mead NJ
David M. Ritchie - Princeton Junction NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 31505
C07D40304

US Classification:

514259

Abstract:

Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.

US Patent:

49635549, Oct 16, 1990

Filed:

Feb 14, 1990

Appl. No.:

7/479796

Inventors:

Donald W. Combs - Piscataway NJ
Robert Falotico - Belle Mead NJ
David M. Ritchie - Princeton Junction NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 31505
C07D40304

US Classification:

514259

Abstract:

Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.

US Patent:

46395180, Jan 27, 1987

Filed:

Sep 24, 1984

Appl. No.:

6/653620

Inventors:

Victor T. Bandurco - Bridgewater NJ
Stanley C. Bell - Narberth PA
Donald W. Combs - Piscataway NJ
Robert Falotico - Belle Mead NJ
Alfonso J. Tobia - Doylestown PA

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

C07D23996

US Classification:

544285

Abstract:

The synthesis of 5,6-dioxy substituted quinazolinediones is described. The novel quinazolinediones are useful as cardiotonic agents.