Donald E Gibson

US Patent:

8357426, Jan 22, 2013

Filed:

Nov 7, 2008

Appl. No.:

12/267400

Inventors:

Charles E. Seeney - Edmond OK, US
William A. Yuill - Edmond OK, US
Donald D. Gibson - Edmond OK, US

Assignee:

Nanomateriales S.A. de C.V. - San Pedro Garza Garcia

International Classification:

B05D 7/00
C09C 1/36
A61K 9/16
A61K 33/00
A61K 9/14

US Classification:

427212, 106436, 106437, 424489, 424490, 424600

Abstract:

A single step milling and surface coating process allows for production of a stable dispersion of surface coated nanoparticles in an efficient manner. The process comprises providing feed particles, providing a coating agent, and generating the stable dispersion of surface coated nanoparticles by milling the feed particles in an aqueous medium containing the coating agent such that the coating agent bonds to surfaces of the feed particles as the feed particles are milled to an average particle size of less than about 100 nm.

US Patent:

20110130616, Jun 2, 2011

Filed:

Jul 17, 2009

Appl. No.:

12/505111

Inventors:

Charles E. Seeney - Edmond OK, US
Jim Klostergaard - Kingwood TX, US
William A. Yuill - Edmond OK, US
Donald D. Gibson - Edmond OK, US

International Classification:

A61N 2/04
A61N 2/00
A61N 2/02
A61K 9/16
A61K 31/335
A61K 9/14
B82Y 5/00

US Classification:

600 14, 600 9, 600 13, 424490, 514449, 424497, 427 214, 977773, 977906

Abstract:

Magnetically responsive therapeutic carriers comprise nanoparticles including single-domain nanoparticles comprising magnetite and having an average particle size ranging between 1 and 50 nanometers, clusters of the single-domain nanoparticles, the clusters having an average cluster size ranging between 5 and 1000 nanometers, and mixtures of the two. The single-domain nanoparticles are encapsulated with a silica coating. A silane coupling agent is bonded to the silica coating and has a specific pendant functional group capable of selectively binding with the therapeutic. Preferably, the bond between the specific pendant functional group and the therapeutic is a covalent bond. The movement of magnetically responsive nanoparticle therapeutic constructs, with concentration and extravasation/endocytosis at a target site, such as cancerous tumors, uses a controllable magnetic field generator adapted to move the therapeutic constructs in three dimensions, and is enhanced using a repetitively-varying magnetic field. A method for treating cancer comprises administering and magnetically guiding a therapeutic construct comprising paclitaxel.

US Patent:

20130121936, May 16, 2013

Filed:

Dec 14, 2012

Appl. No.:

13/715121

Inventors:

Nanomateriales S.A. de C.V. - San Pedro Garza Garcia, MX
William A. Yuill - Edmond OK, US
Donald D. Gibson - Edmond OK, US

Assignee:

Nanomateriales S.A. de C.V. - San Pedro Garza Garcia

International Classification:

B05D 3/12

US Classification:

424 59, 427212, 427215, 106446

Abstract:

A single step milling and surface coating process allows for production of a stable dispersion of surface coated nanoparticles in an efficient manner. The process comprises providing feed particles, providing a coating agent, and generating the stable dispersion of surface coated nanoparticles by milling the feed particles in an aqueous medium containing the coating agent such that the coating agent bonds to surfaces of the feed particles as the feed particles are milled to an average particle size of less than about 100 nm.