Donald D Hansen

US Patent:

20020019563, Feb 14, 2002

Filed:

Mar 23, 2001

Appl. No.:

09/816577

Inventors:

Ronald Webber - St. Charles MO, US
Richard Durley - Chesterfield MO, US
Alok Awasthi - Skokie IL, US
Arija Bergmanis - Des Plaines IL, US
Scott Ganser - Chicago IL, US
Timothy Hagen - Gurne IL, US
E. Hallinan - Evanston IL, US
Donald Hansen - Skokie IL, US
Brian Hickory - Wildwood MO, US
Alan Moormann - Weldon Springs MO, US
Barnett Pitzele - Skokie IL, US
Michelle Promo - Chesterfield MO, US
Richard Schartman - Evanston IL, US
Jeffrey Snyder - Manchester MO, US
Mahima Trivedi - Glenview IL, US
Sofya Tsymbalov - Skokie IL, US

International Classification:

C07C323/25

US Classification:

562/477000, 562/556000

Abstract:

The present invention relates to S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.

US Patent:

20020128510, Sep 12, 2002

Filed:

Sep 15, 2001

Appl. No.:

09/952906

Inventors:

Richard Durley - Chesterfield MO, US
James Sikorski - Atlanta GA, US
Donald Hansen - Skokie IL, US
Michelle Promo - Maryland Hts. MO, US
Ronald Webber - St. Charles MO, US
Barnett Pitzele - Skokie IL, US
Alok Awasthi - Skokie IL, US
Alan Moorman - Weldon Springs MO, US

International Classification:

C07C279/14
A61K031/198

US Classification:

562/560000, 514/565000

Abstract:

The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

US Patent:

20030199701, Oct 23, 2003

Filed:

Dec 17, 2002

Appl. No.:

10/321969

Inventors:

Ronald Webber - St. Charles MO, US
Richard Durley - Chesterfield MO, US
Alok Awasthi - Skokie IL, US
Arija Bergmanis - Des Plaines IL, US
Kam Fok - St. Louis MO, US
Scott Ganser - Chicago IL, US
Timothy Hagen - Gurne IL, US
E. Hallinan - Evanston IL, US
Donald Hansen - Skokie IL, US
Brian Hickory - Wildwood MO, US
Pamela Manning - Labadie MO, US
Michael Mao - Chesterfield MO, US
Alan Moormann - Weldon Springs MO, US
Barnett Pitzele - Skokie IL, US
Michelle Promo - Chesterfield MO, US
Richard Schartman - Evanston IL, US
Jeffrey Scholten - Chesterfield MO, US
Jeffrey Snyder - Manchester MO, US
Mihaly Toth - St. Louis MO, US
Mahima Trivedi - Glenview IL, US
Sofya Tsymbalov - Skokie IL, US
Foe Tjoeng - Ballwin MO, US

Assignee:

Pharmacia Corporate - Chicago IL

International Classification:

C07C323/25
C07D233/76

US Classification:

548/319100, 562/556000

Abstract:

A method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: where the substituents are described herein.

US Patent:

20040186178, Sep 23, 2004

Filed:

Apr 1, 2004

Appl. No.:

10/815375

Inventors:

Ronald Webber - St. Charles MO, US
Richard Durley - Chesterfield MO, US
Alok Awasthi - Skokie IL, US
Arija Bergmanis - Des Plaines IL, US
Kam Fok - St. Louis MO, US
Scott Ganser - Chicago IL, US
Timothy Hagen - Gurne IL, US
E. Hallinan - Evanston IL, US
Donald Hansen - Skokie IL, US
Brian Hickory - Wildwood MO, US
Pamela Manning - Labadie MO, US
Michael Mao - Chesterfield MO, US
Alan Moormann - Weldon Springs MO, US
Barnett Pitzele - Skokie IL, US
Michelle Promo - Chesterfield MO, US
Richard Schartman - Evanston IL, US
Jeffrey Scholten - Chesterfield MO, US
Jeffrey Snyder - Manchester MO, US
Mihaly Toth - St. Louis MO, US
Mahima Trivedi - Glenview IL, US
Foe Tjoeng - Ballwin MO, US

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A61K031/195

US Classification:

514/562000, 560/153000

Abstract:

The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.

US Patent:

20040192779, Sep 30, 2004

Filed:

Apr 7, 2004

Appl. No.:

10/819853

Inventors:

Richard Durley - Chesterfield MO, US
James Sikorski - Atlanta GA, US
Donald Hansen - Skokie IL, US
Michelle Promo - Maryland His MO, US
Ronald Webber - St. Charles MO, US
Barnett Pitzele - Skokie IL, US
Alok Awasthi - Skokie IL, US
Alan Moormann - Weldon Springs MO, US

International Classification:

A61K031/198

US Classification:

514/565000

Abstract:

The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

US Patent:

20050256199, Nov 17, 2005

Filed:

Jul 21, 2005

Appl. No.:

11/186256

Inventors:

Richard Durley - Chesterfield MO, US
James Sikorski - Atlanta GA, US
Donald Hansen - Skokie IL, US
Michelle Promo - Maryland Hts MO, US
Ronald Webber - St. Charles MO, US
Alok Awasthi - Skokie IL, US
Alan Moormann - Weldon Springs MO, US

International Classification:

A61K031/198

US Classification:

514565000

Abstract:

The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

US Patent:

54419506, Aug 15, 1995

Filed:

Jun 9, 1994

Appl. No.:

8/255634

Inventors:

Joe T. Collins - Manchester MO
Donald W. Hansen - Skokie IL
Karen B. Peterson - Vernon Hills IL
Barnett S. Pitzele - Skokie IL
David B. Reitz - Chesterfield MO

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

A61K 3155
C07D26720
C07D28116

US Classification:

514211

Abstract:

The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

US Patent:

55040772, Apr 2, 1996

Filed:

Feb 22, 1995

Appl. No.:

8/393106

Inventors:

Joe T. Collins - Manchester MO
Donald W. Hansen - Skokie IL
Karen H. Peterson - Vernon Hills IL
Barnett S. Pitzele - Skokie IL
David B. Reitz - Chesterfield MO

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

A61K 3155
C07D28116

US Classification:

514211

Abstract:

The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.