Donald R Hansen

US Patent:

20010055798, Dec 27, 2001

Filed:

Jun 6, 2001

Appl. No.:

09/876199

Inventors:

Donald Hansen - Skokie IL, US
Mahima Trivedi - Glenview IL, US
Rolando Gapud - Chicago IL, US
John Ng - Chicago IL, US
Alok Awasthi - Skokie IL, US
Ping Wang - Manchester MO, US

Assignee:

G.D. Searle & Co. - Chicago IL

International Classification:

C07D211/36
C07D223/10
C12P017/10

US Classification:

435/280000, 546/242000, 540/485000

Abstract:

A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid. The hydrolysis product is then separated from the unreacted lactam esters. The enzyme is then recycled for reuse in the next enzymatic resolution. The undesired isomer is also racemized and reused in the next enzymatic resolution.

US Patent:

20020037927, Mar 28, 2002

Filed:

Apr 13, 2001

Appl. No.:

09/834361

Inventors:

Donald Hansen - Skokie IL, US
Ronald Webber - St. Charles MO, US
Alok Awasthi - Skokie IL, US
Pamela Manning - Labadie MO, US

International Classification:

A61K031/198
C07C229/26

US Classification:

514/565000, 562/560000

Abstract:

The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.

US Patent:

20020072630, Jun 13, 2002

Filed:

Sep 15, 2001

Appl. No.:

09/952888

Inventors:

Donald Hansen - Skokie IL, US
Ronald Webber - St. Charles MO, US
Barnett Pitzele - Skokie IL, US
Alok Awasthi - Skokie IL, US
James Sikorski - Atlanta GA, US
Mahima Trivedi - Skokie IL, US

International Classification:

C07C251/00

US Classification:

562/560000

Abstract:

The present invention relates to 2-amino-2-alkyl-3 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors

US Patent:

20020072631, Jun 13, 2002

Filed:

Sep 15, 2001

Appl. No.:

09/954988

Inventors:

Donald Hansen - Skokie IL, US
Ronald Webber - St. Charles MO, US

International Classification:

C07C279/10

US Classification:

562/560000

Abstract:

The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

US Patent:

20020103398, Aug 1, 2002

Filed:

Sep 15, 2001

Appl. No.:

09/952893

Inventors:

Donald Hansen - Skokie IL, US
Mahima Trivedi - Skokie IL, US
Mihaly Toth - St. Louis MO, US
Ronald Webber - St. Charles MO, US
Barnett Pitzele - Skokie IL, US
Alok Awasthi - Skokie IL, US
James Sikorski - Atlanta GA, US

International Classification:

C07C279/10

US Classification:

562/560000

Abstract:

The present invention relates to 2-amino-2-alkyl-4 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.

US Patent:

20020111493, Aug 15, 2002

Filed:

Mar 23, 2001

Appl. No.:

09/816575

Inventors:

Ronald Webber - St. Charles MO, US
Alok Awasthi - Skokie IL, US
Arija Bergmanis - Des Plaines IL, US
Richard Durley - Chesterfield MO, US
Kam Fok - St. Louis MO, US
Scott Ganser - Chicago IL, US
Timothy Hagen - Gurne IL, US
E. Hallinan - Evanston IL, US
Donald Hansen - Skokie IL, US
Brian Hickory - Wildwood MO, US
Pamela Manning - Labadie MO, US
Michael Mao - Chesterfield MO, US
Alan Moormann - Weldon Springs MO, US
Barnett Pitzele - Skokie IL, US
Michelle Promo - Chesterfield MO, US
Richard Schartman - Evanston IL, US
Jeffrey Scholten - Chesterfield MO, US
Jeffrey Snyder - Manchester MO, US
Mihaly Toth - St. Louis MO, US
Mahima Trivedi - Glenview IL, US
Sofya Tsymbalov - Skokie IL, US
Foe Tjoeng - Ballwin MO, US

International Classification:

C07C323/23
C07D211/26

US Classification:

546/231000, 562/556000

Abstract:

The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.

US Patent:

20020119964, Aug 29, 2002

Filed:

Aug 1, 2001

Appl. No.:

09/920612

Inventors:

Donald Hansen - Skokie IL, US
Jeffrey Snyder - Manchester MO, US
Alan Moormann - Weldon Springs MO, US
Alok Awasthi - Skokie IL, US
Ronald Webber - St. Charles MO, US
Thaddeus Franczyk - Chesterfield MO, US
Mahima Trivedi - , US

International Classification:

A61K031/55
C07D498/02
C07D223/10
C07D223/12

US Classification:

514/217110, 540/605000, 540/578000, 540/531000

Abstract:

Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed.

US Patent:

20020132849, Sep 19, 2002

Filed:

Sep 15, 2001

Appl. No.:

09/953049

Inventors:

Donald Hansen - Skokie IL, US
Ronald Webber - St. Charles MO, US
Barnett Pitzele - Skokie IL, US
James Sikorski - Atlanta GA, US
Mark Massa - Ballwin MO, US
Timothy Hagen - Gurnee IL, US
Margaret Grapperhaus - Troy IL, US
Lijuan Wang - Wildwood MO, US
Arija Bergmanis - Des Plaines IL, US
Steven Kramer - Des Plaines IL, US
E. Hallinan - Evanston IL, US

International Classification:

A61K031/198
C07D413/02
C07F007/02

US Classification:

514/563000, 562/560000, 548/110000, 548/132000, 544/138000

Abstract:

The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.