Donald E Ingber from 162 W Canton St, Boston, MA 02118, age 68, Phone: 6172678812

Wikipedia

Dald E. Ingber

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Donald E. Ingber, (born May 1, 1956, East Meadow, NY) is an American cell biologist, Founding Director of the Wyss Institute for Biologically Inspired ...

Us Patents

Adhering Cells To Cytophilic Islands Separated By Cytophobic Regions To Form Patterns And Manipulate Cells
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US Patent:

6368838, Apr 9, 2002
Filed:

Aug 12, 1999
Appl. No.:

09/373334
Inventors:

Rahul Singhvi - Cambridge MA
Amit Kumar - Sacramento CA
George M. Whitesides - Newton MA
Donald E. Ingber - Boston MA
Gabriel P. Lopez - Albuquerque NM
Daniel I. C. Wang - Belmont MA
Gregory N. Stephanopoulos - Winchester MA
Assignee:

President and Fellows of Havard College - Cambridge MA
International Classification:

C12N 1102
US Classification:

435177, 435 29, 435 34, 435180, 435243, 4352831, 4352871, 435395, 435402
Abstract:

Methods and a device are provided for adhering cells in a specific and predetermined position. The device comprises a plate defining a surface and a plurality of cytophilic islands that adhere cells which are isolated by cytophobic regions to which cells do not adhere. The cytophobic regions can be wide enough such that less than 10 percent of the cells adhered to the cytophilic islands are allowed to form bridges across the cytophobic regions and contact each other. Further, the islands or the regions or both may be formed of a self-assembled monolayer (SAM). The methods are for forming a patterned surface for a population of cells and for selectively manipulating individual cells formed on the surface of the plate of the device. Furthermore, the device is used in immobilization of cells at a surface and for controlling shape of the cells.

Orthopedic Implant
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US Patent:

6520996, Feb 18, 2003
Filed:

Jun 5, 2000
Appl. No.:

09/588167
Inventors:

Mark Manasas - Dedham MA
Keith Oslakovic - Cambridge MA
Cornel Sultan - Everett MA
John Hamilton - Foxboro MA
Donald Ingber - Boston MA
Assignee:

DePuy AcroMed, Incorporated - Raynham MA
International Classification:

A61F 244
US Classification:

623 235, 623 1715, 623 214, 623 1714
Abstract:

Disclosed is an orthopedic implant suitable for arthroplasty procedures. The orthopedic implant includes a first plate, a second plate, an axial support between the first plate and the second plate and one or more torsional supports connecting the first plate and the second plate. The axial support may be, for example, one or more flexible struts, such as cables, or a ball and socket joint. The torsional supports connect the first and second plates and may be, for example, curved around the axial support. The torsional supports may be integrally formed with the first and second plates as a single unitary device, by, for example, a Laser Engineered Net Shape (LENS) process.

Differential Treatment Of Selected Parts Of A Single Cell With Different Fluid Components
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US Patent:

6653089, Nov 25, 2003
Filed:

Sep 18, 2001
Appl. No.:

09/954978
Inventors:

Shuichi Takayama - Ann Arbor MI
Emanuele Ostuni - Cambridge MA
Philip LeDuc - Boston MA
Keiji Naruse - Nagoya, JP
Donald E. Ingber - Boston MA
George M. Whitesides - Newton MA
Assignee:

President and Fellows of Harvard College - Cambridge MA
Childrens Medical Center Corporation - Boston MA
International Classification:

G01N 3353
US Classification:

435 772, 435 78, 435 29, 435377, 435378, 435396, 435397, 435402, 4352871
Abstract:

The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a biophysical or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.

Patterning Of Surfaces Utilizing Microfluidic Stamps Including Three-Dimensionally Arrayed Channel Networks
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US Patent:

6686184, Feb 3, 2004
Filed:

May 25, 2000
Appl. No.:

09/578562
Inventors:

Janelle R. Anderson - Cambridge MA
Daniel T. Chiu - Seattle WA
Sui Huang - Boston MA
Ravi Kane - Cambridge MA
Insung S. Choi - Cambridge MA
Donald E. Ingber - Boston MA
George M. Whitesides - Newton MA
Assignee:

President and Fellows of Harvard College - Cambridge MA
Childrens Medical Center Corporation - Boston MA
International Classification:

C12N 1100
US Classification:

435174, 435176, 435177, 435180, 4352831, 536810, 536811, 536812, 536815
Abstract:

Microfluidic systems and methods are provided for fabricating complex patterns of materials, such as proteins, inorganic materials or cells, on surfaces. Complex, discontinuous patterns on surfaces can be formed incorporating or depositing multiple materials. A stamp structure has a flow path containing a series of interconnected channels. The channels include a first channel within an interior of the stamp structure, a second channel within a stamping surface of the structure defining a pattern, and a channel fluidically interconnecting the first and second channels. After contacting the stamp with a surface, a fluid is introduced into the flow path so that the fluid contacts the surface to form a pattern. In another embodiment, the stamp structure has two non-fluidically interconnected first and second flow paths defining first and second patterns of channels to produce non-continuous first and second patterns on a surface.

Orthopedic Implant
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US Patent:

6802867, Oct 12, 2004
Filed:

Dec 20, 2002
Appl. No.:

10/324200
Inventors:

Mark Manasas - Dedham MA
Keith Oslakovic - Cambridge MA
Cornel Sultan - Everett MA
John Hamilton - Foxboro MA
Donald Ingber - Boston MA
Assignee:

DePuy AcroMed, Inc. - Raynham MA
International Classification:

A61F 244
US Classification:

623 235, 623 1714, 623 1715, 623 214
Abstract:

Disclosed is an orthopedic implant suitable for arthroplasty procedures. The orthopedic implant includes a first plate, a second plate, an axial support between the first plate and the second plate and one or more torsional supports connecting the first plate and the second plate. The axial support may be, for example, one or more flexible struts, such as cables, or a ball and socket joint. The torsional supports connect the first and second plates and may be, for example, curved around the axial support. The torsional supports may be integrally formed with the first and second plates as a single unitary device, by, for example, a Laser Engineered Net Shape (LENS) process.

Method And Apparatus For Displaying Information
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US Patent:

6888543, May 3, 2005
Filed:

May 9, 2003
Appl. No.:

10/435660
Inventors:

Donald E. Ingber - Boston MA, US
Sui Huang - Boston MA, US
Gabriel Eichler - Cambridge MA, US
Assignee:

Children's Medical Center Corporation - Boston MA
International Classification:

G06T017/00
US Classification:

345420, 345782, 345788
Abstract:

A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.

Device Containing Cytophilic Islands That Adhere Cells Separated By Cytophobic Regions
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US Patent:

7067306, Jun 27, 2006
Filed:

Dec 21, 2001
Appl. No.:

10/032280
Inventors:

Rahul Singhvi - Cambridge MA, US
Amit Kumar - Sacramento CA, US
George M. Whitesides - Newton MA, US
Donald E. Ingber - Boston MA, US
Gabriel P. Lopez - Albuquerque NM, US
Daniel I. C. Wang - Belmont MA, US
Gregory N. Stephanopoulos - Winchester MA, US
Assignee:

President & Fellows of Harvard College - Cambridge MA
International Classification:

C12Q 1/02
C12Q 1/04
C12N 11/02
C12N 11/08
US Classification:

4352831, 435 30, 435 34, 435177, 435180, 435243, 4352521, 4352524, 4352536, 4352541, 4352551, 4352568, 4352871, 4352891, 435395, 435402, 4354821, 435 29
Abstract:

The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).

Selective Deposition Of Materials On Countoured Surfaces
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US Patent:

7288394, Oct 30, 2007
Filed:

Sep 23, 2003
Appl. No.:

10/668679
Inventors:

Emanuele Ostuni - Watertown MA, US
Christopher S. Chen - Baltimore MD, US
Donald E. Ingber - Boston MA, US
George M. Whitesides - Newton MA, US
Assignee:

President & Fellows of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA
International Classification:

C12N 11/02
C12N 11/08
C07K 17/02
C07K 17/08
US Classification:

435177, 435180, 530812, 530815
Abstract:

A method of patterning materials, such as proteins, on a contoured surface by depositing them onto protrusions on a surface, and a cell containment device that may be constructed by this method, are provided. The method may involve selectively depositing a material on a substrate including a contoured surface including protrusions and recesses. By applying a first fluid to the contoured surface and allowing the first fluid to distribute across only a portion of the contoured surface, a material may be deposited on the protrusions and not the recesses, or on the recesses and not the protrusions. Such a method may be used to selectively pattern cells or other materials on substrates.