Donald James Kyle

US Patent:

6635653, Oct 21, 2003

Filed:

Apr 18, 2002

Appl. No.:

10/126506

Inventors:

R. Richard Goehring - Pipersville PA
Gary Lee - West Windsor NJ
Parviz Gharagozloo - Pennington PA
Sam Victory - Newtown PA
Donald Kyle - Newtown PA

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

A61K 31438

US Classification:

514278, 546 19, 546 20

Abstract:

A compound of the formula (I): wherein Z, W, A, B, C, R , R , Q and n are as disclosed herein.

US Patent:

6825205, Nov 30, 2004

Filed:

Sep 24, 2003

Appl. No.:

10/668326

Inventors:

Donald J. Kyle - Newtown PA

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

A61K 31485

US Classification:

514282, 546 45, 546 44

Abstract:

This invention relates to N-substituted hydromorphones of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is C alkyl. These compounds act as opioid receptor agonists. The invention is also directed to the use of compounds of Formula I for the treatment, prevention or amelioration of both acute and chronic pain.

US Patent:

6828440, Dec 7, 2004

Filed:

Apr 18, 2002

Appl. No.:

10/126472

Inventors:

R. Richard Goehring - Pipersville PA
Sam Vicotry - Newton PA
Donald Kyle - Newtown PA

Assignee:

Euro-Celtique, S.A.

International Classification:

C07D47110

US Classification:

546 17, 514278

Abstract:

A compound of the formula (I): wherein Z, A, B, C, R , R , X , X , Q and n are as disclosed herein.

US Patent:

6861421, Mar 1, 2005

Filed:

Apr 18, 2002

Appl. No.:

10/126507

Inventors:

R. Richard Goehring - Pipersville PA, US
Zhengming Chen - Belle Mead NJ, US
John Whitehead - Newtown PA, US
Parviz Gharagozloo - Pennington NJ, US
Sam Victory - Newtown PA, US
Donald Kyle - Newtown PA, US

Assignee:

Euro-Celtique S.A - Luxembourg

International Classification:

C07D417/04
C07D417/14
A61K031/5415
A61P029/00
A61P037/08

US Classification:

5142228, 544 11, 546199, 546158

Abstract:

A compound of the having the general formula (I) or general formula (II): wherein.

US Patent:

6864261, Mar 8, 2005

Filed:

May 2, 2003

Appl. No.:

10/429078

Inventors:

Parviz Gharagozloo - Pennington NJ, US
Khondaker Islam - Langhorne PA, US
Donald J. Kyle - Newtown PA, US
Qun Sun - Princeton NJ, US
Laykea Tafesse - Robinsville NJ, US
John William Frank Whitehead - Newtown PA, US
Ji Yang - Princeton Junction NJ, US
Xiaoming Zhou - Plainsboro NJ, US

Assignee:

Euro-Celtique S.A.

International Classification:

A61K031/496
C07D401/04

US Classification:

51425301, 544360, 544364

Abstract:

A compound of formula (wherein A, R, R, R, m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Piperazine Compound”); pharmaceutical compositions comprising a Piperazine Compound; and methods for treating pain, urinary incontinence (UI), an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia and depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.

US Patent:

6867222, Mar 15, 2005

Filed:

Apr 18, 2002

Appl. No.:

10/126471

Inventors:

Qun Sun - Belle Mead NJ, US
R. Richard Goehring - Pipersville PA, US
Donald Kyle - Newtown PA, US
Zhengming Chen - Belle Mead NJ, US
Sam Victory - Newtown PA, US
John Whitehead - Newtown PA, US

Assignee:

Euro-Celtique, S.A. - Luxembourg

International Classification:

A61K031/495
C07D401/04

US Classification:

514322, 546199

Abstract:

A compound of the formula (I), (II), (III) or (IV).

US Patent:

6872733, Mar 29, 2005

Filed:

Apr 18, 2002

Appl. No.:

10/126437

Inventors:

R. Richard Goehring - Pipersville PA, US
Zhengming Chen - Belle Mead NJ, US
Sam Victory - Newtown PA, US
Donald Kyle - Newtown PA, US

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

A61K031/445
C07D401/04

US Classification:

514322, 546199

Abstract:

Disclosed are compounds of the formula (I): wherein A, B, C, M-M, R, R, Rand n are as described herein.

US Patent:

6956038, Oct 18, 2005

Filed:

Jul 16, 2002

Appl. No.:

10/195530

Inventors:

Qun Sun - Princeton NJ, US
Donald J. Kyle - Newtown PA, US

Assignee:

Euro-Celtique S.A. - Luxembourg

International Classification:

A61K031/426
A61K031/4439
C07D277/14
C07D417/06

US Classification:

5142368, 514326, 514342, 514369, 544133, 546209, 5462697, 548186

Abstract:

This invention relates aryl substituted thiazolidinones of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein Rand R, are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.