William H. Yanko - Centerville OH Donald E. Sharp - Dayton OH
Assignee:
The United States of America as represented by the Secretary of the Department of Health, Education and Welfare - Washington DC
International Classification:
C07C12715
US Classification:
260553R
Abstract:
A method of producing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) by nitrosation of 1,3-bis(2-chloroethyl)-urea utilizing as a nitrosating agent dinitrogen trioxide (N. sub. 2 O. sub. 3) in molar excess of theoretical wherein the molar excess of N. sub. 2 O. sub. 3 ranges from 10-200% and preferably from 10-20%. The nitrosation reaction is conventionally carried out in the cold from 0. degree. C to -20. degree. C and a non-aqueous solvent is utilized. The preferred non-aqueous solvent is of the chlorinated variety; i. e. , methylene dichloride. Other preferred solvents include related halogenated compounds such as ethylene dichloride, nitro-compounds such as nitromethane, acetonitrile, and simple ethers such as ethyl ether. Other less preferred but operable compounds include esters such as ethyl acetate, simple ketones such as acetones, and chloroform. Solvents to be avoided are olefins, unsaturated ethers and other unsaturated compounds, amines, malonate esters, acid anhydrides, and solvents which would interact with the reactant N. sub. 2 O. sub.
Slagle Mechanical 2006 - 2008
Shipping and Recieving
Sidney Win Industry 2006 - 2008
Warehouse Shipping and Receiving
Ctl 2003 - 2006
Field Test Inspector
Education:
Sidney High School
Skills:
Stocking Shelves Filling Orders Delivering Testing Concrete Checking Foundations Willing To Learn Something New
Dr. Sharp graduated from the University of Tennessee College of Medicine at Memphis in 1974. He works in Oak Ridge, TN and specializes in Dermatology. Dr. Sharp is affiliated with Methodist Medical Center.
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Googleplus
Donald Sharp
Work:
Cisco Systems, Inc.
Education:
Virginia Polytechnic Institute and State University - Computer Engineering, Osbourn Park High School