Donald A Tomalia

US Patent:

6471968, Oct 29, 2002

Filed:

May 12, 2000

Appl. No.:

09/570198

Inventors:

Donald A. Tomalia - Ann Arbor MI

Assignee:

Regents of the University of Michigan - Ann Arbor MI

International Classification:

C07H 2104

US Classification:

4242801, 424 111, 4242771, 424 941, 4241301, 514 44, 536 231, 536 241, 536 245

Abstract:

The present invention relates to novel therapeutic and diagnostic arrays. More particularly, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e. g. , cancer diagnosis and therapy). The compositions and systems generally comprise two or more separate components for targeting, imaging, sensing, and/or triggering release of a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e. g. , a tumor).

US Patent:

6475994, Nov 5, 2002

Filed:

Dec 23, 1998

Appl. No.:

09/219907

Inventors:

Donald A. Tomalia - Midland MI 48640
Lajos Balogh - Ann Arbor MI

Assignee:

Donald A. Tomalia - Midland MI

International Classification:

A61K 3170

US Classification:

514 44, 435 914, 4353201, 435455, 424486, 424497

Abstract:

A gene transfection particle includes a polymer, a support particle conjugated with the dendritic polymer, and genetic material conjugated with the dendritic polymer. The gene transfection particles are highly efficient and are capable of delivering higher quantities of genetic materials to cells, with reduced cell damage. A gene transfection method involves bombarding cells with conjugates of polymers and genetic material, with or without a support particle.

US Patent:

6632889, Oct 14, 2003

Filed:

Aug 2, 1999

Appl. No.:

09/365609

Inventors:

Rui Yin - Newark DE 19711
Donald A. Tomalia - Midland MI 48640
Dujie Qin - Ann Arbor MI 48105
Jamie Dunham - Midland MI 48640

International Classification:

C08J27102

US Classification:

525279, 525280, 525417

Abstract:

A method of forming a branched polymer includes forming a plurality of growing linear polymer chains by polymerizing a monomer which is protected against branching and which forms a reactive end group which is in a first condition which is one of electrophilic or nucleophilic, exposing the growing linear polymer chains to a chain transfer agent to cause the reactive end group of at least a first growing linear polymer chain to reverse its electrophilic or nucleophilic character, whereby a non-reversed reactive end group on a second growing linear polymer chain reacts with the reversed reactive end group on the first growing linear polymer chain to create a branched polymer and reverses the electrophilic or nucleophilic character of the reversed reactive end group back to its first condition, whereby it may continue adding monomer in a linear fashion; and quenching the polymerization by adding a compound having multiple reactive sites capable of reacting with the reactive end groups of the polymer chains when they are in the first condition. The method allows the preparation of ultra-high molecular weight dendritic polymers in which the branching junctures are assembled in situ (i. e. , are self-branching) in a convergent manner during polymerization of the monomers.

US Patent:

6635720, Oct 21, 2003

Filed:

Jan 24, 2002

Appl. No.:

09/913050

Inventors:

Donald A. Tomalia - Midland MI
Srinivas Uppuluri - Ypsilanti MI
Douglas R. Swanson - Mt. Pleasant MI

Assignee:

Dendritech Inc. - Midland MI

International Classification:

C08L 7700

US Classification:

525432, 424DIG 16

Abstract:

Core-shell tecto(dendrimers) useful in biomedicine, pharmaceuticals, personal care products, and in other ways analogous to the known uses for dendrimers, hypercomb branched polymers, and other dendritic polymers are the reaction product of a core dendritic polymer molecule having a plurality of terminal functional groups of a first type which are not reactive with each other, and a plurality of shell dendritic polymer molecules having a plurality of terminal functional groups of a second type which are not reactive with each other, but which are reactive with the terminal functional groups of the first type. Each of the shell dendritic polymer molecules is chemically bonded to the core dendritic polymer molecule by a reaction of at least one of the terminal functional groups of the second type with at least one of the terminal functional groups of the first type.

US Patent:

6664315, Dec 16, 2003

Filed:

Feb 10, 2001

Appl. No.:

09/780973

Inventors:

Donald A. Tomalia - Midland MI
Lajos Balogh - Midland MI

Assignee:

The Dow Chemical Company - Midland MI

International Classification:

C08J 300

US Classification:

523218, 523205, 524504, 528480

Abstract:

In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/are subsequently transformed to form a reaction product which is immobilized with respect to the dendritic polymer. This immobilization occurs on a nanoscopic scale as a consequence of the combined effects of structural, chemical and physical changes without having covalent bonds between the product(s) and the dendritic container and results in new compositions of matter called dendritic nanocomposites. The resulting nanocomposite material can be used to produce revolutionary products such as water soluble elemental metals, with specific applications including magnetic resonance imaging, catalytic, magnetic, optical, photolytic and electroactive applications.

US Patent:

6995234, Feb 7, 2006

Filed:

Oct 9, 2003

Appl. No.:

10/682646

Inventors:

Donald A. Tomalia - Midland MI, US
Lajos Balogh - Midland MI, US

Assignee:

The Dow Chemical Company - Midland MI

International Classification:

C08K 3/00
C08J 9/00

US Classification:

528490, 528487, 528489, 523105, 523205, 523218, 524504, 424486, 424501

Abstract:

In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/are subsequently transformed to form a reaction product which is immobilized with respect to the dendritic polymer. This immobilization occurs on a nanoscopic scale as a consequence of the combined effects of structural, chemical and physical changes without having covalent bonds between the product(s) and the dendritic container and results in new compositions of matter called dendritic nanocomposites. The resulting nanocomposite material can be used to produce revolutionary products such as water soluble elemental metals, with specific applications including magnetic resonance imaging, catalytic, magnetic, optical, photolytic and electroactive applications.

US Patent:

7005124, Feb 28, 2006

Filed:

Oct 29, 2001

Appl. No.:

10/016733

Inventors:

Navid Malik - London, GB
Ruth Duncan - London, GB
Donald A. Tomalia - Midland MI, US
Roseita Esfand - Mt. Pleasant MI, US

Assignee:

Dendritic Nanotechnologies, Inc. - Mt. Pleasant MI

International Classification:

A61K 47/48
A61K 33/24
A61K 31/80

US Classification:

424 7817, 424 7821, 424DIG 16

Abstract:

Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to an antineoplastic agent capable of interacting with the functional groups, and contacting the dendritic polymer with the antineoplastic agent. The preferred platin-based analogues of the antineoplastic agents conjugated to the dendritic polymer may be administered intravenously, orally, parentally, subcutaneously, intramuscularly, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, reduced toxicity, and improved anti-tumor activity in vivo.

US Patent:

7078461, Jul 18, 2006

Filed:

May 8, 2003

Appl. No.:

10/431956

Inventors:

Donald A. Tomalia - Midland MI, US
Istvan J. Majoros - Ypsilanti MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C08L 67/00
C08G 63/48

US Classification:

525 43, 525 50, 525 543, 525 55

Abstract:

The present invention relates to compositions and methods involving biocompatible dendrimers. In particular, the present invention provides dendrimeric copolymers with poly(propyleneimine) (POPAM) interiors and poly(amidoamine) (PAMAM) exteriors for use in transfection and imaging applications.