Donald J Wolff

US Patent:

20030027870, Feb 6, 2003

Filed:

May 15, 2002

Appl. No.:

10/147453

Inventors:

Stephen Wilson - Chatham NJ, US
Donald Wolff - Bridgewater NJ, US
David Schuster - Wilton CT, US
Christine Richardson - Hastings-on-Hudson NY, US
Alexandru Dragos Papoiu - Piscataway NJ, US
John Alford - Lakewood CO, US

International Classification:

A61K031/135
A61K031/05

US Classification:

514/656000, 514/732000

Abstract:

This invention provides novel fullerene derivatives, particularly fullerene derivatives that are water-soluble, that modulate the activity of nitric oxide synthase (NOS) and/or calmodulin. The invention provides methods for modulating NOS activity and particularly provides methods for inhibiting NOS activity, by contacting one or more fullerene derivatives of this invention with cells or tissue that exhibit NOS activity. In a specific embodiment, the invention provides water-soluble fullerene derivatives that are selective inhibitors of neuronal NOS or iNOS. Preferred water soluble fullerenes have substituents that contain one or more amine groups, amine cationic groups. More generally, water-soluble fullerenes of this invention contain one or more polar, one or more charged or more zwitterionic groups