Donna L Stone

Address:

1101 Boast Rd, White Hall, AR 71602

Phone:

8705439552

VIN:

WAUGGAFC8CN147558

Make:

AUDI

Model:

A6

Year:

2012

US Patent:

6407216, Jun 18, 2002

Filed:

Sep 20, 1999

Appl. No.:

09/398239

Inventors:

Frederick J. de Sauvage - Foster City CA
Arnon Rosenthal - Pacifica CA
Donna M. Stone - Brisbane CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 1628

US Classification:

53038822, 530350, 5303871, 5303879, 5303881, 5303891, 536 231, 536 235

Abstract:

Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.

US Patent:

6492139, Dec 10, 2002

Filed:

Apr 27, 2000

Appl. No.:

09/560876

Inventors:

Frederic J. de Sauvage - Foster City CA
Arnon Rosenthal - Burlingame CA
Donna M. Stone - Brisbane CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C12N 1512

US Classification:

435 691, 536 231, 536 235, 530350, 4353201, 435325, 4352523, 43525411

Abstract:

Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.

US Patent:

7144996, Dec 5, 2006

Filed:

Mar 2, 2000

Appl. No.:

09/581742

Inventors:

Frederic J. de Sauvage - Foster City CA, US
Maximilien Murone - Epalinges, CH
Arnon Rosenthal - Burlingame CA, US
Donna M. Stone - Brisbane CA, US
Austin L. Gurney - Belmont CA, US
William I. Wood - Hillsborough CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 1/00
C07H 21/04
C12N 1/20
C12P 21/06
G01N 33/567

US Classification:

536 235, 530350, 514 2, 435 6, 435 72, 435 721, 435 691, 4352523, 4353201, 436501

Abstract:

The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the melanogaster fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

US Patent:

7579161, Aug 25, 2009

Filed:

Apr 1, 2005

Appl. No.:

11/096396

Inventors:

Frederic J. de Sauvage - Foster City CA, US
Maximilien Murone - Epalinges, CH
Arnon Rosenthal - Burlingame CA, US
Donna M. Stone - Brisbane CA, US
Austin L. Gurney - Belmont CA, US
William I. Wood - Hillsborough CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

G01N 33/53
G01N 33/58

US Classification:

435 78, 435 79, 435 8

Abstract:

The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

US Patent:

20030170228, Sep 11, 2003

Filed:

Aug 2, 2002

Appl. No.:

10/210951

Inventors:

Avi Ashkenazi - San Mateo CA, US
Audrey Goddard - San Francisco CA, US
Paul Godowski - Hillsborough CA, US
Austin Gurney - Belmont CA, US
Kenneth Hillan - San Francisco CA, US
Scot Marsters - San Carlos CA, US
James Pan - Belmont CA, US
Robert Pitti - El Cerrito CA, US
Margaret Roy - San Francisco CA, US
Victoria Smith - Burlingame CA, US
Donna Stone - Brisbane CA, US
Colin Watanabe - Moraga CA, US
William Wood - Hillsborough CA, US

Assignee:

Genentech, Inc.

International Classification:

A61K039/395
C12P021/04
C12N005/16
C12N005/06
C07K016/40
C07H021/04

US Classification:

424/130100, 435/326000, 435/070210, 530/388100, 435/320100, 536/023530

Abstract:

The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

US Patent:

20030175900, Sep 18, 2003

Filed:

Aug 2, 2002

Appl. No.:

10/211884

Inventors:

Avi Ashkenazi - San Mateo CA, US
Audrey Goddard - San Francisco CA, US
Paul Godowski - Hillsborough CA, US
Austin Gurney - Belmont CA, US
Kenneth Hillan - San Francisco CA, US
Scot Marsters - San Carlos CA, US
James Pan - Belmont CA, US
Robert Pitti - El Cerrito CA, US
Margaret Roy - San Francisco CA, US
Victoria Smith - Burlingame CA, US
Donna Stone - Brisbane CA, US
Colin Watanabe - Moraga CA, US
William Wood - Hillsborough CA, US

Assignee:

Genentech, Inc.

International Classification:

C12P021/04
C07H021/04
A61K039/395
C12P021/02
C12N005/06
C07K016/40

US Classification:

435/071200, 435/070210, 435/326000, 424/130100, 530/388100, 536/023530, 435/320100

Abstract:

The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

US Patent:

20030211096, Nov 13, 2003

Filed:

Aug 2, 2002

Appl. No.:

10/211858

Inventors:

Avi Ashkenazi - San Mateo CA, US
Audrey Goddard - San Francisco CA, US
Paul Godowski - Hillsborough CA, US
Austin Gurney - Belmont CA, US
Kenneth Hillan - San Francisco CA, US
Scot Marsters - San Carlos CA, US
James Pan - Belmont CA, US
Robert Pitti - El Cerrito CA, US
Margaret Roy - San Francisco CA, US
Victoria Smith - Burlingame CA, US
Donna Stone - Brisbane CA, US
Colin Watanabe - Moraga CA, US
William Wood - Hillsborough CA, US

Assignee:

Genentech, Inc.

International Classification:

A61K039/395
C07H021/04
C12P021/02
C12N005/06
C07K016/40

US Classification:

424/130100, 435/326000, 530/388100, 435/320100, 435/069100, 536/023530

Abstract:

The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

US Patent:

59902817, Nov 23, 1999

Filed:

Sep 30, 1996

Appl. No.:

8/720484

Inventors:

Frederic J. de Sauvage - Foster City CA
Arnon Rosenthal - Pacifica CA
Donna M. Stone - Brisbane CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 1447
C12N 1512

US Classification:

530350

Abstract:

Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.