Nov 2007 to Present HousekeepingRooms-To-Go Brandon, FL Jun 2005 to Nov 2007 ReceptionistHome Depot Tampa, FL Sep 2002 to Mar 2005 Customer Service RepresentativeMini Vacation Tampa, FL Feb 2000 to Dec 2001 Sales Representative
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Dorothy Rodriguez Secretary
All D's Corp
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Us Patents
Method And Composition For Inhibition Of Angiogenesis Using Antagonists Based On Mmp-9 And Β1 Integrins
Peter C. Brooks - West Harrison NY, US Dorothy Rodriguez - West Harrison NY, US
Assignee:
University of Southern California - Los Angeles CA
International Classification:
C07K 16/00 A61K 38/00
US Classification:
5303871, 5303877, 5303881, 530300
Abstract:
Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are described. Such antagonists inhibit angiogenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are also described.
Method And Composition For Inhibition Of Angiogenesis Using Antagonists Based On Mmp-9 And Β1 Integrins
Peter C. Brooks - West Harrison NY, US Dorothy Rodriguez - West Harrison NY, US
Assignee:
University of Southern California - Los Angeles CA
International Classification:
A61K 39/395
US Classification:
4241301
Abstract:
Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are described. Such antagonists inhibit angiogenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are also described.
Inhibition Of Melanogenesis And Melanoma Metastasis With P-Aminobenzoic Acid (Paba)
The present invention provides methods and compositions for inhibiting angiogenesis, tumor growth and treating disease states using a peptide that contains a specific amino acid sequence of matrix metalloproteinase 2 (MMP-2). In one embodiment, the invention provides a peptide, which comprises the amino acid sequence Ile-Phe-Ala-Gly-Asp-Lys-Phe-Trp-Arg, preferably flanked by cysteine residues at the amino and carboxy termini. Additionally, the invention provides compositions for inhibiting angiogenesis or tumor growth or for treating disease states comprising organic and non-peptidic mimetics based on the above amino acid sequence as well as optimized sequences flanking the region of MMP-2 within which the sequence lies. Also provided are methods for detecting angiogenesis, tumorous tissue, metastases, and tumor invasion into a tissue by contacting a composition of the invention with a tissue and methods for screening compositions of the invention.
Inhibition Of Melanogenesis And Melanoma Metastasis With P-Amino Benzoic Acid (Paba)