Dorothy Rodriguez

age ~55

from Astoria, NY

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Dorothy Rodriguez Phones & Addresses

Method And Composition For Inhibition Of Angiogenesis Using Antagonists Based On Mmp-9 And Β1 Integrins
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US Patent:

7101975, Sep 5, 2006
Filed:

Jul 13, 2000
Appl. No.:

09/615624
Inventors:

Peter C. Brooks - West Harrison NY, US
Dorothy Rodriguez - West Harrison NY, US
Assignee:

University of Southern California - Los Angeles CA
International Classification:

C07K 16/00
A61K 38/00
US Classification:

5303871, 5303877, 5303881, 530300
Abstract:

Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are described. Such antagonists inhibit angiogenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are also described.

Method And Composition For Inhibition Of Angiogenesis Using Antagonists Based On Mmp-9 And Β1 Integrins
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US Patent:

7566449, Jul 28, 2009
Filed:

Mar 25, 2005
Appl. No.:

11/089999
Inventors:

Peter C. Brooks - West Harrison NY, US
Dorothy Rodriguez - West Harrison NY, US
Assignee:

University of Southern California - Los Angeles CA
International Classification:

A61K 39/395
US Classification:

4241301
Abstract:

Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are described. Such antagonists inhibit angiogenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are also described.

Novel Method And Composition For Inhibition Of Angiogenesis And Tumor Growth Using Compounds Based On A Sequence Within Mmp-2
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US Patent:

20020182215, Dec 5, 2002
Filed:

Jun 1, 2001
Appl. No.:

09/872165
Inventors:

Peter Brooks - West Harrison NY, US
Dorothy Rodriguez - West Harrison NY, US
International Classification:

A61K048/00
A61K039/395
A61K038/48
C12N009/99
C07K016/30
US Classification:

424/155100, 424/094100, 514/044000, 435/184000, 530/388800
Abstract:

The present invention provides methods and compositions for inhibiting angiogenesis, tumor growth and treating disease states using a peptide that contains a specific amino acid sequence of matrix metalloproteinase 2 (MMP-2). In one embodiment, the invention provides a peptide, which comprises the amino acid sequence Ile-Phe-Ala-Gly-Asp-Lys-Phe-Trp-Arg, preferably flanked by cysteine residues at the amino and carboxy termini. Additionally, the invention provides compositions for inhibiting angiogenesis or tumor growth or for treating disease states comprising organic and non-peptidic mimetics based on the above amino acid sequence as well as optimized sequences flanking the region of MMP-2 within which the sequence lies. Also provided are methods for detecting angiogenesis, tumorous tissue, metastases, and tumor invasion into a tissue by contacting a composition of the invention with a tissue and methods for screening compositions of the invention.