Douglas Wayne English

US Patent:

20090311332, Dec 17, 2009

Filed:

Mar 6, 2009

Appl. No.:

12/382041

Inventors:

Philip R. DeShong - Silver Spring MD, US
Michael R. Zachariah - Potomac MD, US
Peter DeMuth - Towson MD, US
Anand Prakash - Wilmington MA, US
Charles Luckett - Greenbelt MD, US
Douglas Stephen English - Wichita KS, US

International Classification:

A61K 9/14
A61K 31/704
A61P 35/00

US Classification:

424489, 514 34, 977906, 977773

Abstract:

A method for synthesizing a mesoporous silica nanoparticle, a mesoporous silica nanoparticle, and applications thereof are provided. The method includes fractionating a mesoporous silica nanoparticle suspension to produce size-fractionated mesoporous silica nanoparticle. The method further includes etching the size-fractionated mesoporous silica nanoparticle to produce synthesized mesoporous silica nanoparticle having a hollow, porous morphology configured to receive one of a therapeutic agent and an imaging material. The etching includes differential etching of silica from areas of low polymeric density within the mesoporous silica nanoparticle and re-depositing of the silica in areas of higher polymeric density existing near the surface of the mesoporous silica nanoparticle. A target material is loaded into the synthesized mesoporous silica nanoparticle and a controlled released of the target material is provided by decreasing the physiological pH of the surface of the mesoporous silica nanoparticle.

US Patent:

20200261415, Aug 20, 2020

Filed:

May 8, 2020

Appl. No.:

16/869745

Inventors:

- Wichita KS, US
Douglas S. English - Derby KS, US

International Classification:

A61K 31/407
C07D 487/22
A01N 43/90
C07D 273/08
C07D 321/00
A01N 43/72
A01N 43/22
A61P 31/04
A61K 31/357
A61K 31/395

Abstract:

Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.

US Patent:

20190029998, Jan 31, 2019

Filed:

Jul 27, 2018

Appl. No.:

16/048009

Inventors:

- Wichita KS, US
Douglas S. English - Derby KS, US

International Classification:

A61K 31/407
A61K 31/395
A61K 31/357
A61P 31/04

Abstract:

Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.