Douglas Andrew English

US Patent:

20070249063, Oct 25, 2007

Filed:

Aug 30, 2005

Appl. No.:

11/214012

Inventors:

Philip Deshong - Silver Spring MD, US
Douglas English - Silver Spring MD, US
Daniel Stein - Silver Spring MD, US
Mridula Kadalbajoo - Central Islip NY, US
Fehmi Damkaci - Brighton MA, US

International Classification:

G01N 33/543
C12Q 1/68

US Classification:

436518000, 977902000, 435006000

Abstract:

Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached to the surface of the substrate and wherein the ligand preferentially binds to a receptor.

US Patent:

20080305157, Dec 11, 2008

Filed:

Jun 9, 2008

Appl. No.:

12/155758

Inventors:

Douglas S. English - College Park MD, US
Srinivasa Raghavan - College Park MD, US
Philip R. DeShong - College Park MD, US
Xiang Wang - College Park MD, US
Emily J. Danoff - College Park MD, US
Jaeho Lee - College Park MD, US

Assignee:

University of Maryland Office of Technology Commercialization - College Park MD

International Classification:

A61K 9/127
C11B 3/00
C12N 15/87
C12N 5/06

US Classification:

424450, 554124, 435375, 435458

Abstract:

Catanionic vesicles including solute ion, methods for forming these, and methods of using these.

US Patent:

20090075396, Mar 19, 2009

Filed:

Sep 10, 2008

Appl. No.:

12/232075

Inventors:

Philip R. Deshong - College Park MD, US
Douglas S. English - College Park MD, US
Daniel C. Stein - College Park MD, US
Mridula Kadalbajoo - College Park MD, US
Fehmi Damkaci - College Park MD, US

Assignee:

University of Maryland Office of Technology Commercialization - College Park MD

International Classification:

G01N 33/553
G01N 33/552
G01N 33/551

US Classification:

436525, 436527, 436524, 977902

Abstract:

Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached to the surface of the substrate and wherein the ligand preferentially binds to a receptor.

US Patent:

20090311332, Dec 17, 2009

Filed:

Mar 6, 2009

Appl. No.:

12/382041

Inventors:

Philip R. DeShong - Silver Spring MD, US
Michael R. Zachariah - Potomac MD, US
Peter DeMuth - Towson MD, US
Anand Prakash - Wilmington MA, US
Charles Luckett - Greenbelt MD, US
Douglas Stephen English - Wichita KS, US

International Classification:

A61K 9/14
A61K 31/704
A61P 35/00

US Classification:

424489, 514 34, 977906, 977773

Abstract:

A method for synthesizing a mesoporous silica nanoparticle, a mesoporous silica nanoparticle, and applications thereof are provided. The method includes fractionating a mesoporous silica nanoparticle suspension to produce size-fractionated mesoporous silica nanoparticle. The method further includes etching the size-fractionated mesoporous silica nanoparticle to produce synthesized mesoporous silica nanoparticle having a hollow, porous morphology configured to receive one of a therapeutic agent and an imaging material. The etching includes differential etching of silica from areas of low polymeric density within the mesoporous silica nanoparticle and re-depositing of the silica in areas of higher polymeric density existing near the surface of the mesoporous silica nanoparticle. A target material is loaded into the synthesized mesoporous silica nanoparticle and a controlled released of the target material is provided by decreasing the physiological pH of the surface of the mesoporous silica nanoparticle.

US Patent:

20110165067, Jul 7, 2011

Filed:

Aug 18, 2008

Appl. No.:

12/673844

Inventors:

Douglas S. English - College Park MD, US
Philip R. DeShong - College Park MD, US
Daniel C. Stein - College Park MD, US
Sara Lioi - College Park MD, US
Ju-Hee Park - College Park MD, US
Emily J. Danoff - College Park MD, US
Glen B. Thomas - College Park MD, US

Assignee:

University of Maryland Office of Technology Commercialization - College Park MD

International Classification:

A61K 51/04
A61K 9/00
A61K 9/127
A61K 51/08
A61K 38/02
A61K 31/70
A61K 31/715
A61K 31/7052
A61K 31/7088
A61K 31/704
A61K 49/00
A61K 35/00
C40B 40/12
C40B 40/10
G01N 33/80
C40B 30/04
C12N 1/00
C12N 5/071
C12N 15/63
G01N 33/68
A61P 35/00
A61P 31/00
A61P 37/02
A61P 37/04

US Classification:

424 121, 424400, 424450, 514 11, 514 23, 514 54, 514 43, 514 44 R, 514 34, 424 91, 424 931, 506 19, 506 18, 436501, 506 9, 435243, 435375, 435440, 4242781

Abstract:

Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these.

US Patent:

20120252703, Oct 4, 2012

Filed:

Dec 2, 2011

Appl. No.:

13/310579

Inventors:

Matthew Dowling - Washington DC, US
Srinivasa R. Raghavan - Silver Spring MD, US
Neeraja Dashaputre - College Park MD, US
Douglas Stephen English - Derby KS, US
Vishal Javvaji - Chantilly VA, US
Gregory F. Payne - Hunt Valley MD, US
Philip R. DeShong - Silver Spring MD, US

Assignee:

University of Maryland,College Park Office of Technology and Commercialization - College Park MD

International Classification:

G01N 33/533
C25D 9/02
C25D 5/34
C40B 60/08

US Classification:

506 37, 422 69, 205317, 205211

Abstract:

A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle binding molecule. The biosensor is manufactured by a method where a modified chitosan biopolymer is electrodeposited on a substrate. The method is also used to manufacture a modified chitosan biopolymer film by electrodeposition of the chitosan on the substrate and later removing the film from the substrate after electrodeposition. The resulting film can be used in bandages to treat various types of wounds. The biosensor can also be used to detect various analytes in samples.