Douglas M Mccarty

Address:

114 Ponder Pl SW, Pataskala, OH 43062

VIN:

WAUHF78PX7A053348

Make:

AUDI

Model:

A3

Year:

2007

US Patent:

7790154, Sep 7, 2010

Filed:

Jan 19, 2007

Appl. No.:

11/655520

Inventors:

Richard Jude Samulski - Chapel Hill NC, US
Douglas M. McCarty - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapell Hill NC

International Classification:

C12N 15/86
C12N 15/00
C12N 15/64
A61K 48/00

US Classification:

424 931, 424 932, 424 9321, 424 936, 435456, 435455, 435 914, 435 9141, 435 9142

Abstract:

The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.

US Patent:

8361457, Jan 29, 2013

Filed:

Aug 2, 2010

Appl. No.:

12/848756

Inventors:

Richard Jude Samulski - Chapel Hill NC, US
Douglas M. McCarty - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C12N 15/86
C12N 15/00
C12N 15/64
A61K 48/00

US Classification:

424 931, 424 932, 424 9321, 424 936, 435456, 435455, 435 914, 435 9141, 435 9142

Abstract:

The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.

US Patent:

20040029106, Feb 12, 2004

Filed:

Jan 21, 2003

Appl. No.:

10/276356

Inventors:

Richard Samulski - Chapel Hill NC, US
Douglas McCarty - Chapel Hill NC, US

International Classification:

C12Q001/70
C12N007/00

US Classification:

435/005000, 435/235100, 435/320100

Abstract:

The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.

US Patent:

20130039888, Feb 14, 2013

Filed:

Jun 7, 2012

Appl. No.:

13/491326

Inventors:

Douglas M. McCarty - Pataskala OH, US
Haiyan Fu - Pataskala OH, US

Assignee:

NATIONWIDE CHILDREN'S HOSPITAL INC. - Columbus OH

International Classification:

A61K 48/00
A61P 3/00
C12N 15/63

US Classification:

424 932, 4353201

Abstract:

The present invention relates to methods and materials useful for systemically delivering polynucleotides across the blood brain barrier using adeno-associated virus as a vector. For example, the present invention relates to methods and materials useful for systemically delivering α-N-acetylglucosamidinase polynucleotides to the central and peripheral nervous systems, as well as the somatic system. Use of these methods and materials is indicated, for example, for treatment of the lysosomal storage disorder mucopolysaccharidosis IIIB. As another example, the present invention relates to methods and materials useful for systemically delivering N-sulphoglucosamine sulfphohydrolase polynucleotides to the central and peripheral nervous systems, as well as the somatic system. Use of this second type of methods and materials is indicated, for example, for treatment of the lysosomal storage disorder mucopolysaccharidosis IIIA.

US Patent:

20130252325, Sep 26, 2013

Filed:

Jan 28, 2013

Appl. No.:

13/751819

Inventors:

Douglas M. McCarty - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C12N 15/864

US Classification:

4353201

Abstract:

The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.