Disclosed herein are methods and composition for alteration of the presence, activity, or concentration of RNF138. Disclosed methods can be utilized to affect DNA double strand break repair. Methods and compositions can be utilized to alter RNF138 so as to prevent interaction between RNF138 and RAD51D. Specifically, methods can prevent RNF138-directed ubiquitylation of RAD51D, which is necessary for DNA double strand break repair.
Marin County Sheriff's Department Lt. Douglas Pittman tells television station KGO (http://abc7ne.ws/1mVD8Kh ) that search teams worked through the night looking for Ida Rothschild, who was visiting Samuel P. Taylor State Park with her parents and two younger boys on Friday afternoon when she disapp