Douglas G Robinson

Address:

PO Box 1558, Hamilton, MT 59840

Phone:

4103533868

VIN:

1GC1KXE8XCF100033

Make:

CHEVROLET

Model:

SILVERADO 2500HD

Year:

2012

US Patent:

8187857, May 29, 2012

Filed:

Mar 17, 2005

Appl. No.:

10/593800

Inventors:

Douglas H. Robinson - Washington DC, US

Assignee:

Denovo Biologic LLC - Arlington VA

International Classification:

C12N 1/00
C12N 1/12
C12N 5/00

US Classification:

435243, 4352521, 435325

Abstract:

The present invention relates to pleomorphic cells (“morphotes”), which exhibit morphologic and genetic characteristics of both prokaryotic and eukaryotic cells, including resemblance to prokaryotic cells at the unicellular level, and resemblance to eukaryotic cells at the multicellular level due to their ability to self-organize in vitro into multicellular, mammalian tissue-like patterns consisting of tissue-like sheets, capillary-like networks, and trabecular (spongy) bone-like structures. Morphotes have a number of applications in the diagnostic medical, therapeutic medical, biological, biomaterials, bionanotechnological, and industrial fields.

US Patent:

20010018214, Aug 30, 2001

Filed:

Jan 16, 2001

Appl. No.:

09/759345

Inventors:

Douglas Robinson - Washington DC, US

International Classification:

C12N015/03
C12N015/02
C12N015/04
C12N015/08

US Classification:

435/454000

Abstract:

Bacteria containing eukaryotic and/or viral genes, and often having highly pleiomorphic morphology, are obtained by culturing virally-infected eukaryotic cells under aseptic, low oxygen conditions. The bacteria so produced express products encoded by the eukaryotic genes. Analyses indicate that several isolates obtained from culturing retrovirally-infected human brain capillary endothelial cells express human-specific genes previously mapped to widely separated human chromosomes.

US Patent:

51802228, Jan 19, 1993

Filed:

Nov 6, 1991

Appl. No.:

7/788370

Inventors:

Douglas J. Robinson - Washington DC

International Classification:

A47F 1110

US Classification:

362125

Abstract:

The present invention provides a display cabinet for displaying an object from a plurality of views, in which the observer's own image is not reflected. According to the present invention, at least one reflective surface such as mirrors are provided within a cabinet. The mirrors define an internal display chamber within the cabinet, with one of the faces of the display chamber constituting a viewing window having a special coating which allows some of the interior light to escape the display chamber. The lighting in the display chamber is controlled so as to ensure that more light exits the viewing window than enters from outside the display cabinet, thus ensuring that the observer's image is not reflected.

US Patent:

60227303, Feb 8, 2000

Filed:

Sep 25, 1996

Appl. No.:

8/719367

Inventors:

Douglas H. Robinson - Washington DC

International Classification:

C12Q 104
C12N 516
C12N 508

US Classification:

4352523

Abstract:

Bacteria containing eukaryotic and/or viral genes, and often having highly pleiomorphic morphology, are obtained by culturing virally-infected eukaryotic cells under aseptic, low oxygen conditions. The bacteria so produced express products encoded by the eukaryotic genes. Analyses indicate that several isolates obtained from culturing retrovirally-infected human brain capillary endothelial cells express human-specific genes previously mapped to widely separated human chromosomes.

US Patent:

55997031, Feb 4, 1997

Filed:

Oct 28, 1993

Appl. No.:

8/142569

Inventors:

Thomas A. Davis - Chantilly VA
Steven Kessler - Cupertino CA
Douglas H. Robinson - Washington DC

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C12N 500
A01N 6300
A01N 6500

US Classification:

435373

Abstract:

The present invention relates to a method of amplifying in vitro stemcells. In this method hematopoietic CD34. sup. + stem and progenitor cells are isolated from human bone marrow and contacted with endothelial cells. The contacted stem cells and endothelial cells are cultured in the presence of at least one cytokine in an amount sufficient to support amplification/expansion of the hematopoietic CD34. sup. + stem and progenitor cells. This method produces increased yields of hematopoietic CD34. sup. + stem and progenitor cells which can be used in human therapeutics.

US Patent:

47216735, Jan 26, 1988

Filed:

Mar 6, 1984

Appl. No.:

6/587029

Inventors:

Jack R. Uren - Gaithersburg MD
Douglas E. Robinson - Frederick MD
Carl J. Scandella - Oakland CA

Assignee:

Genex Corporation - Gaithersburg MD

International Classification:

C12N 900
C12N 952

US Classification:

435183

Abstract:

A process for the extraction and activation of microbially produced bovine prochymosin is disclosed.

US Patent:

20210145746, May 20, 2021

Filed:

Dec 12, 2018

Appl. No.:

16/772518

Inventors:

- Baltimore MD, US
Takanari Inoue - Lutherville-Timonium MD, US
Tianzhi Luo - Hefei, Anhui, CN
Douglas Robinson - Lutherville-Timonium MD, US

International Classification:

A61K 9/127

Abstract:

This application is directed to methods which allow for encapsulation of an array of biological materials under physiological conditions that are relevant given a biological context and the compositions made using those methods. These reconstituted biological materials encompass: a) purified proteins that can bind to the lipid membranes inside and outside of vesicles based on the electrostatic charge; b) purified cytosolic proteins that position themselves in the lumen of the vesicles, c) mammalian cell extracts with an array of cytosolic protein content, among other contents and d) small biological molecules such as DNA and RNA as well as fluorescent dyes/probes. These vesicles can be used to simulate cells in drug discovery methods as well as useful in administering drugs and other compositions to cells in vitro and in vivo.

US Patent:

20200230213, Jul 23, 2020

Filed:

Oct 1, 2018

Appl. No.:

16/652501

Inventors:

- Baltimore MD, US
Douglas Robinson - Lutherville MD, US
Ramana Sidhaye - Clarksville MD, US
Jennifer Nguyen - Baltimore MD, US

International Classification:

A61K 38/45
G01N 33/50
C12N 15/86
C12N 9/12

Abstract:

Described are method of treating or preventing lung disease in a subject comprising the steps of: administering to a subject an agent that modulates the expression, the amount, or activity, of adenine nucleotide translocase (ANT) in the lungs of a subject. The treatment enhances airway surface (ASL) thickness in the lung of a subject compared to a lung of a reference subject that has not been given the agent.