Affinia Therapeutics
Senior Director, Translational Sciences
Sarepta Therapeutics
Associate Director, Translational Development
Merck Kgaa, Darmstadt, Germany Jul 2016 - Aug 2017
Principal Scientist - Clinical Biomarker and Companion Diagnostic Development
Novartis Apr 2015 - Jun 2016
Principal Scientist
Novartis Oct 2013 - Apr 2015
Senior Scientist
Education:
University of Missouri - Columbia 1996 - 2007
Doctorates, Doctor of Philosophy, Philosophy, Veterinary Pathology
University of Missouri - Columbia 1992 - 1996
Bachelors, Bachelor of Science
Skills:
Molecular Biology Assay Development Qpcr Cell Culture Flow Cytometry Pcr Polymerase Chain Reaction Confocal Microscopy Biomarker Development Real Time Polymerase Chain Reaction Animal Models Molecular Cloning Fluorescence Microscopy Bacterial Transformation Immunofluorescence Bacterial Cell Culture Adult Stem Cells Gene Therapy Recombinant Dna Technology Facs Analysis Six Sigma Analytical Method Validation Digital Pcr Embryonic Stem Cells Protocol Design Immunohistochemistry Sequence Analysis Electron Microscopy Translational Research Design of Experiments Regulatory Documentation Risk Assessment Molecular Oncology Fda Quality Auditing Supplier Quality Management Technical Writing Design Control Product Requirements Analytical Methods Development Enzyme Replacement Therapy Orphan Disease Research Quantitative Imaging Genome Wide Association Whole Genome Sequencing Ffpe Dna Extraction
Certifications:
Design For Six Sigma (Dfss) Green Belt Novartis Companion Diagnostics
Construction Defence and Security Infrastructure International Construction Projects Municipal Law and Other Government Procurement Public-Private Infrastructure Projects Railway Saskatchewan
ISLN:
914228750
Admitted:
1990
University:
University of Saskatchewan, 1986; University of Saskatchewan, 1986
Construction & Development Energy and Natural Resources Environmental Investigations and Business Crimes Litigation Dispute Resolution Climate Change Environmental Law: Advisory/Disputes Environmental Litigation Internal Investigations and White-Collar Crime Product Liability and Product Recall Renewable Energy
ISLN:
913236336
Admitted:
1998
University:
Georgetown University School of Foreign Service, 1994
Jeffrey William Breti - Nashua NH, US Douglas Elliott Sanders - Framingham MA, US Harish Bharadwaj - Redwood City CA, US Suparna Behera - Cupertino CA, US Gordon Douglas Boyd - Arlington MA, US Richard John Bombard - Marlborough MA, US
Assignee:
LSI Corporation - Milpitas CA
International Classification:
G06F 19/00 G06F 3/00
US Classification:
710 29, 710 33
Abstract:
A method and apparatus is provided wherein a central Credit Controller Entity (CCE) is connected to a PCIE fabric environment by means of several buses. Flow Control information sent to the CCE over two of the buses indicates the buffer storage capacity that is available at respective Receiver components in the PCIE fabric. The CCE processes the Flow Control information, to generate updates that are sent by a third bus to Transmitter components corresponding to the Receivers. In one useful embodiment, directed to a method of Flow Control management, the CCE provides a repository adapted to store credit count information that represents the available storage capacity of respective Receivers. The method further comprises routing further credit count information from a given Receiver to the CCE, for storage in the repository, following each of successive events that affect the storage capacity of the given Receiver. The CCE is operated to selectively process the credit count information stored in the repository, in order to generate an update credit count.
Bridge Apparatus And Methods For Coupling Multiple Non-Fibre Channel Devices To A Fibre Channel Arbitrated Loop
James W. Keeley - Hollis NH, US Douglas E. Sanders - Framingham MA, US Andrew Hyonil Chong - San Jose CA, US
Assignee:
LSI Corporation - Milpitas CA
International Classification:
H04L 12/56
US Classification:
370401
Abstract:
Apparatus and methods for an enhanced bridge device for coupling multiple non-Fiber Channel storage devices to a Fiber Channel Arbitrated Loop (FC-AL) communication medium. Features and aspects hereof provide for FC-AL enhanced circuits for processing loop port bypass (LPB) and loop port enable (LPE) primitive sequences addressed to any target arbitrated loop physical address (T-ALPA) associated with a storage device coupled with the bridge regardless of the present bypassed/non-bypassed status of other T-ALPAs processed by the bridge device and associated with other storage devices coupled with the bridge device.
Apparatus And Methods For Access Fairness For A Multiple Target Bridge/Router In A Fibre Channel Arbitrated Loop System
James W. Keeley - Hollis NH, US Douglas E. Sanders - Framingham MA, US Daniel W. Meyer - Brentwood CA, US Andrew Hyonil Chong - San Jose CA, US Ju-Ching Tang - Fremont CA, US
Assignee:
LSI Corporation - San Jose CA
International Classification:
H04J 3/02
US Classification:
370462
Abstract:
Apparatus and methods improved fair access to a Fiber Channel Arbitrated Loop (FC-AL) communication medium through a bridge device. The enhanced bridge device provides for a fair access in a currently open access window for all presently requesting devices coupled through the bridge device to the FC-AL communication medium. Thus all devices on the loop whether coupled directly or through a bridge device can be assured fair access to the loop when there are simultaneous requests during an open access window.
Rebecca L. Stamm - Boston MA R. Iris Bahar - Belmont MA Michael Callander - Hudson MA Linda Chao - Chelmsford MA Derrick R. Meyer - Watertown MA Douglas Sanders - Framingham MA Richard L. Sites - Boylston MA Raymond Strouble - Southbridge MA Nicholas Wade - Marlborough MA
Assignee:
Digital Equipment Corporation - Maynard MA
International Classification:
G06F 1100
US Classification:
395575
Abstract:
A pipelined CPU executing instructions of variable length, and referencing memory using various data widths. Macroinstruction pipelining is employed (instead of microinstruction pipelining), with queueing between units of the CPU to allow flexibility in instruction execution times. A wide bandwidth is available for memory access; fetching 64-bit data blocks on each cycle. A hierarchical cache arrangement has an improved method of cache set selection, increasing the likelihood of a cache hit. A writeback cache is used (instead of writethrough) and writeback is allowed to proceed even though other accesses are suppressed due to queues being full. A branch prediction method employs a branch history table which records the taken vs. not-taken history of branch opcodes recently used, and uses an empirical algorithm to predict which way the next occurrence of this branch will go, based upon the history table. A floating point processor function is integrated on-chip, with enhanced speed due to a bypass technique; a trial mini-rounding is done on low-order bits of the result, and if correct, the last stage of the floating point processor can be bypassed, saving one cycle of latency.
Apparatus For Suppressing An Error Report From An Address For Which An Error Has Already Been Reported
Michael A. Callander - Hudson MA Linda Chao - Chelmsford MA Douglas E. Sanders - Framingham MA
Assignee:
Digital Equipment Corporation - Maynard MA
International Classification:
G06F 1100
US Classification:
395575
Abstract:
A write-back cache memory system is disclosed which includes a source of a sequence of memory addresses and a tag store coupled to the source of addresses and accessed by an index portion of said addresses, which produces information relating to the addresses. The write-back cache memory system also includes an error detector for detecting an error in the tag store information. Circuitry is included for reporting an error and saving the index which caused the error if an error is detected but no error has been previously detected. Comparing circuitry is included for comparing the index causing the current error to the previously saved address if an error is detected and an error has been previously detected; and if the address is not the same, then reporting a fatal error; otherwise, if the index is the same, then not reporting a fatal error.
Application Of State Silos For Recovery From Memory Management Exceptions
William C. Madden - Lexington MA Douglas E. Sanders - Framingham MA G. Michael Uhler - Marlborough MA William R. Wheeler - Hudson MA
Assignee:
Digital Equipment Corporation - Maynard MA
International Classification:
G06F 938 G06F 1100
US Classification:
395375
Abstract:
To reduce the processing time required for correcting a fault, the instruction decorder segment and the first execution segment of a pipelined processor are provided with "state silos" that are operative during normal instruction execution to save a sufficient amount of state information to immediately restart the instruction decoder segment and the first execution segment by reloading the state information having been stored in the state silos. The state silos, for example, include a queue of registers clocked by a common clocking signal that is inhibited during correction of the fault. When the fault is corrected, multiplexers select the state information from the silos to be used by the respective pipeline segments. In a preferred embodiment, the instruction decoder segment decodes variable length macroinstructions into operand specifiers and operations to perform upon the specifiers. The first execution segment receives control information when a new operand specifier or operation is decoded, and otherwise holds the previously received control information.
- Waltham MA, US Roberto CALCEDO DEL HOYO - Concord MA, US Douglas N. SANDERS - Hudson NH, US Lisa M. STANEK - Natick MA, US Samantha SMITH - Watertown MA, US Richard LU - Somerville MA, US Christopher TIPPER - Cambridge MA, US Robert Steven Johnson - Oundle, GB
Assignee:
AFFINIA THERAPEUTICS INC. - Waltham MA
International Classification:
C12N 15/861 C12N 15/74 A61P 25/28
Abstract:
The disclosure pertains to a recombinant adeno-associated virus (rAAV) comprising an Anc80L65 capsid for delivering a polynucleotide (e.g., a transgene) into the central nervous system (CNS). Further provided includes methods for treating CNS diseases using the rAAV and pharmaceutical compositions comprising the rAAV.