Douglas M Young

US Patent:

6837858, Jan 4, 2005

Filed:

Oct 5, 2001

Appl. No.:

09/972444

Inventors:

David D. Cunningham - Lake Villa IL, US
Timothy P. Henning - Vernon Hills IL, US
Eric B. Shain - Glencoe IL, US
Douglas F. Young - Grayslake IL, US
Andrew J. Muetterties - Mundelein IL, US
Thomas G. Schapira - Bristol WI, US
Geoffrey R. Chambers - Middlesex, GB
Graham J. Hughes - Oxford, GB
Jared L. Watkin - Oxon, GB
Gary F. Prokop - Wheaton IL, US
Joshua P. Goldfarb - Chicago IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 500

US Classification:

600573

Abstract:

Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e. g. , glucose monitoring. In one aspect of the invention, the method comprises the steps of:In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:.

US Patent:

60931566, Jul 25, 2000

Filed:

Dec 2, 1997

Appl. No.:

8/982721

Inventors:

David D. Cunningham - Lake Villa IL
Timothy P. Henning - Vernon Hills IL
Eric B. Shain - Glencoe IL
Douglas F. Young - Grayslake IL
Andrew J. Muetterties - Mundelein IL
Thomas G. Schapira - Bristol WI
Geoffrey R. Chambers - Middlesex, GB
Graham J. Hughes - Oxford, GB
Jared L. Watkin - Oxon, GB
Gary F. Prokop - Wheaton IL
Joshua P. Goldfarb - Chicago IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 500

US Classification:

600573

Abstract:

Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e. g. , glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) placing a blood collection device over a region on the surface of the skin from which said sample is to be obtained, (b) forming a seal between said blood collection device and said surface of the skin, (c) creating a vacuum sufficient to result in said surface of the skin becoming stretched and engorged with blood, (d) triggering a lancing assembly and causing a lancet to penetrate said skin, (e) retracting said lancet, (f) withdrawing blood toward and onto a fluid collector, and (g) releasing the vacuum. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a housing having a sealable chamber located therein and a sealable opening in fluid communication with said sealable chamber, (b) a power source, (c) a vacuum pump operably connected to said power source, said vacuum pump in communication with said sealable chamber, (d) a lancing assembly positioned within said housing, said lancing assembly capable of moving a lancet towards said sealable opening, and (e) a fluid collector positioned in said sealable chamber, said fluid collector in fluid communication with said sealable opening.

US Patent:

6155992, Dec 5, 2000

Filed:

Dec 2, 1997

Appl. No.:

8/982449

Inventors:

Timothy P. Henning - Vernon Hills IL
Robert G. Hiltibran - Bristol WI
David D. Cunningham - Lake Villa IL
Eric B. Shain - Glencoe IL
Brian J. Tarkowski - Lake Villa IL
Douglas F. Young - Grayslake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 500

US Classification:

600583

Abstract:

A method and apparatus for obtaining a sample of interstitial fluid from a patient for subsequent diagnostic tests, e. g. , glucose monitoring. In one aspect of the invention, the method comprises the steps of (a) treating an area of the skin with vacuum or heat or both vacuum and heat to increase the availability of interstitial fluid at that area of the skin; (b) forming an opening in the treated area of the skin; and (c) extracting the sample of interstitial fluid from the opening in the skin, with the aid of vacuum and stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. Th apparatus comprises (a) a device for forming an unobstructed opening in the area of the skin from which the sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing.

US Patent:

61601535, Dec 12, 2000

Filed:

Feb 3, 2000

Appl. No.:

9/498388

Inventors:

Christopher Bieniarz - Highland Park IL
Douglas F. Young - Grayslake IL
Michael J. Cornwell - Morton Grove IL
Zbigniew Skrzypczynski - Vernon Hills IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07F 9165

US Classification:

558160

Abstract:

The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO. sub. 3. sup. --2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided. Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality. Q--(S--PO. sub. 3. sup. -2). sub. n (I) The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C. sub. 1 -C. sub. 5 alkyl and CONH(CH. sub. 2). sub.

US Patent:

6306104, Oct 23, 2001

Filed:

Jul 10, 2000

Appl. No.:

9/612722

Inventors:

David D. Cunningham - Lake Villa IL
Timothy P. Henning - Vernon Hills IL
Eric B. Shain - Glencoe IL
Douglas F. Young - Grayslake IL
Andrew J. Muetterties - Mundelein IL
Thomas G. Schapira - Bristol WI
Geoffrey R. Chambers - Middlesex, GB
Graham J. Hughes - Oxford, GB
Jared L. Watkin - Oxon, GB
Gary F. Prokop - Wheaton IL
Joshua P. Goldfarb - Chicago IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 500

US Classification:

600573

Abstract:

Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e. g. , glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) placing a blood collection device over a region on the surface of the skin from which said sample is to be obtained, (b) forming a seal between said blood collection device and said surface of the skin, (c) creating a vacuum sufficient to result in said surface of the skin becoming stretched and engorged with blood, (d) triggering a lancing assembly and causing a lancet to penetrate said skin, (e) retracting said lancet, (f) withdrawing blood toward and onto a fluid collector, and (g) releasing the vacuum. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a housing having a sealable chamber located therein and a sealable opening in fluid communication with said sealable chamber, (b) a power source, (c) a vacuum pump operably connected to said power source, said vacuum pump in communication with said sealable chamber, (d) a lancing assembly positioned within said housing, said lancing assembly capable of moving a lancet towards said sealable opening, and (e) a fluid collector positioned in said sealable chamber, said fluid collector in fluid communication with said sealable opening.

US Patent:

63128888, Nov 6, 2001

Filed:

Oct 16, 2000

Appl. No.:

9/688636

Inventors:

Sie Ting Wong - Mundelein IL
Robert G. Hiltibran - Bristol WI
Tung-Ming Huang - Buffalo Grove IL
Brenda B. Calfin - Chicago IL
Mark R. Pope - Grayslake IL
Thomas G. Schapira - Bristol WI
Eric B. Shain - Glencoe IL
Douglas F. Young - Grayslake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12Q 100

US Classification:

435 4

Abstract:

An article and a method for monitoring the concentration of an analyte, e. g. , glucose, in blood. In one aspect, the invention involves an article comprising a multiple-layer element. In one embodiment, the article comprises: a multiple-layer element comprising: (a) a base layer (b) a cover layer, the cover layer having a first opening for venting the multiple-layer element and a second opening for receiving a biological sample; and (c) a core layer having a first major surface and a second major surface, the core layer disposed between the base layer and the cover layer, the core layer comprising a sample introduction chamber and a optical reading chamber, the first major surface of the core layer in face-to-face contact with the base layer, the second major surface of the core layer in face-to-face contact with the cover layer. The multiple-layer element of this invention allows the use of samples of blood or other biological fluids, such as interstitial fluid, to provide extremely sensitive assay results. The device has been shown to provide accurate and reproducible results with samples having volumes ranging from about 5. mu.

US Patent:

62839268, Sep 4, 2001

Filed:

Mar 22, 2000

Appl. No.:

9/532729

Inventors:

David D. Cunningham - Lake Villa IL
Timothy P. Henning - Vernon Hills IL
Eric B. Shain - Glencoe IL
Douglas F. Young - Grayslake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 500

US Classification:

600573

Abstract:

Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e. g. , glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and (b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing.

US Patent:

60574291, May 2, 2000

Filed:

May 29, 1996

Appl. No.:

8/657695

Inventors:

Christopher Bieniarz - Highland Park IL
Douglas F. Young - Grayslake IL
Michael J. Cornwell - Morton Grove IL
Zbigniew Skrzypczynski - Vernon Hills IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07K 1700
C07F 916

US Classification:

530402

Abstract:

The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO. sub. 3. sup. -2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided. Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality. Q--(S--PO. sub. 3. sup. -2). sub. n (I) The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C. sub. 1 -C. sub. 5 alkyl and CONH(CH. sub. 2). sub.