Edward Curtis Ball

US Patent:

6340569, Jan 22, 2002

Filed:

Nov 12, 1998

Appl. No.:

09/189926

Inventors:

Edward D. Ball - San Diego CA
Rui-Kun Zhong - San Diego CA

Assignee:

University of Pittsburgh - Pittsburgh PA

International Classification:

G01N 3353

US Classification:

435 72, 435 29, 435325, 435326, 4353722, 5303887, 53038873

Abstract:

Disclosed herein are hybridomas, antibodies produced thereby, antigens, and cells identified or isolated therewith. The dendritic like cells preferably have dendritic morphology and B cell phenotype. Methods of utilizing the hybridomas, antibodies, antigens, and cells are also discussed herein.

US Patent:

7977320, Jul 12, 2011

Filed:

Oct 28, 2005

Appl. No.:

11/718127

Inventors:

Edward D. Ball - San Diego CA, US
Larissa Balaian - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A01N 43/04
A61K 31/70

US Classification:

514 43, 514 42, 514 49, 514 45

Abstract:

The present invention provides compositions and methods for increasing the amount of active Syk protein kinase and or SHP-1 protein phosphatase in a cell. The compositions and methods are useful for increasing the efficacy of anti-neoplastic agents, such as those that target the CD33 protein, and which are used to treat leukemia. The invention thus provides for treatment of cancers, including leukemias. The invention also provides screening assays for anti-neoplastic agents in vitro. Methods of screening patients for responsiveness to anti-CD33 treatments are also provided.