Edward David Ball

US Patent:

6340569, Jan 22, 2002

Filed:

Nov 12, 1998

Appl. No.:

09/189926

Inventors:

Edward D. Ball - San Diego CA
Rui-Kun Zhong - San Diego CA

Assignee:

University of Pittsburgh - Pittsburgh PA

International Classification:

G01N 3353

US Classification:

435 72, 435 29, 435325, 435326, 4353722, 5303887, 53038873

Abstract:

Disclosed herein are hybridomas, antibodies produced thereby, antigens, and cells identified or isolated therewith. The dendritic like cells preferably have dendritic morphology and B cell phenotype. Methods of utilizing the hybridomas, antibodies, antigens, and cells are also discussed herein.

US Patent:

6423759, Jul 23, 2002

Filed:

Dec 20, 2000

Appl. No.:

09/742974

Inventors:

Steven L. Schilling - Pittsburgh PA
Herman P. Doerge - Pittsburgh PA
Edward E. Ball - Weirton WV
Keith J. Headley - Paden City WV

Assignee:

Bayer Corporation - Pittsburgh PA

International Classification:

C08G 1808

US Classification:

521174, 25218224, 25218225, 25218226, 25218227, 521128, 521129

Abstract:

A co-initiated polyether polyol is produced by suspending a solid polyhydroxyl compound in an amine-initiated polyol, heating the suspension and alkoxylating the heated suspension. These co-initiated polyether polyols are particularly useful for the production of polyurethanes.

US Patent:

6617368, Sep 9, 2003

Filed:

Nov 13, 2001

Appl. No.:

10/008551

Inventors:

David D. Steppan - Gibsonia PA
Alan D. Bushmire - McDonald PA
Edward E. Ball - Weirton WV

Assignee:

Bayer Corporation - Pittsburgh PA

International Classification:

C08G 1848

US Classification:

521159, 521137, 521174, 521176

Abstract:

This invention relates to a process for the preparation of an isotropic rigid foam comprising the step of reacting: (A) an organic polyisocyanate component selected from the group consisting of: (1) a polymethylene poly(phenylisocyanate) and (2) an NCO-terminated prepolymer, and comprising the reaction product of: (a) a polyester comprising the reaction product of (i) pure ortho-phthalic acid or phthalic anhydride and (ii) a glycol and (b) a polymethylene poly(phenylisocyanate); with (B) an isocyanate-reactive component comprising: (1) a liquid OH-terminated prepolymer having a viscosity of more than about 100,000 mPaÂs at 25Â C. , and which comprises the reaction product of: (a) an organic aromatic polyisocyanate component; and (b) an amine initiated polyether polyol component; (2) at least one polyether polyol and optionally (3) at least one aromatic polyester polyol; in the presence of: (C) at least one catalyst; and (D) at least one blowing agent; wherein the relative amounts of components present is such that the Isocyanate Index is from 90 to 170. This invention also relates to the isotropic rigid foams prepared thereby.

US Patent:

7619014, Nov 17, 2009

Filed:

May 23, 2002

Appl. No.:

10/154028

Inventors:

Steven L. Schilling - Pittsburgh PA, US
Edward E. Ball - Weirton WV, US

Assignee:

Bayer MaterialScience LLC - Pittsburgh PA

International Classification:

C08G 18/28

US Classification:

521117, 521130, 521131, 521174

Abstract:

A rigid polyurethane foam having lose density without an increased k-factor can be produced by adding small amounts of butyl alcohol to a polyurethane composition containing an isocyanate, at least one polyol, a catalyst and a gaseous blowing agent.

US Patent:

7977320, Jul 12, 2011

Filed:

Oct 28, 2005

Appl. No.:

11/718127

Inventors:

Edward D. Ball - San Diego CA, US
Larissa Balaian - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A01N 43/04
A61K 31/70

US Classification:

514 43, 514 42, 514 49, 514 45

Abstract:

The present invention provides compositions and methods for increasing the amount of active Syk protein kinase and or SHP-1 protein phosphatase in a cell. The compositions and methods are useful for increasing the efficacy of anti-neoplastic agents, such as those that target the CD33 protein, and which are used to treat leukemia. The invention thus provides for treatment of cancers, including leukemias. The invention also provides screening assays for anti-neoplastic agents in vitro. Methods of screening patients for responsiveness to anti-CD33 treatments are also provided.

US Patent:

8097660, Jan 17, 2012

Filed:

Aug 31, 2006

Appl. No.:

11/513767

Inventors:

V. Michael Mautino - Finleyville PA, US
Steven L. Schilling - Pittsburgh PA, US
Edward E. Ball - Weirton WV, US

Assignee:

Bayer MaterialScience LLC - Pittsburgh PA

International Classification:

C08G 18/00

US Classification:

521170, 521155, 521172, 521174

Abstract:

Rigid closed-cell polyurethane foams with low k-factors are produced by reacting an organic polyisocyanate with an amine-based polyether polyol and a polyester polyol in the presence of a catalyst and a hydrofluorocarbon blowing agent, preferably, HFC-245fa. It is preferred that no water be added to the reaction mixture.

US Patent:

20010005747, Jun 28, 2001

Filed:

Dec 12, 2000

Appl. No.:

09/735173

Inventors:

Edward Ball - Wexford PA, US
Michael Fanger - Lebanon NH, US

Assignee:

Medarex, Inc.

International Classification:

A61K039/395
C07K016/00
C12P021/08

US Classification:

530/388800, 424/130100

Abstract:

Bispecific molecules comprising a target cell specific ligand and an effector cell specific antibody or functional antibody fragment are disclosed.

US Patent:

20040082675, Apr 29, 2004

Filed:

Oct 28, 2002

Appl. No.:

10/281733

Inventors:

Steven Schilling - Pittsburgh PA, US
Edward Ball - Weirton WV, US

International Classification:

C08G018/00

US Classification:

521/155000

Abstract:

Rigid foams having good insulation properties are made by reacting a polyisocyanate with an isocyanate-reactive material in the presence of a blowing agent mixture composed of from about 1 to 70% by weight of a low boiling hydrogen containing chlorofluorocarbon, such as chlorodifluoromethane (HCFC-22) and from 30 to 99% by weight of a C-Cpolyfluoroalkane, such as 1,1,1,3,3-pentafluoropropane (HFC-245fa).