Edward W Doherty

US Patent:

50026615, Mar 26, 1991

Filed:

Aug 25, 1989

Appl. No.:

7/398739

Inventors:

William L. Chick - Wellesley MA
Susan J. Sullivan - Newton MA
Kermit M. Borland - Worcester MA
John M. Harvey - Worcester MA
Thomas E. Muller - Concord MA
Karen E. Dunleavy - Billerica MA
Donald P. King - Haverhill MA
Edward J. Doherty - Waltham MA
Barry A. Solomon - Bedford MA
Amy L. Foley - Framingham MA

Assignee:

W. R. Grace & Co.-Conn. - Lexington MA

International Classification:

B01D 6306

US Classification:

210192

Abstract:

A device which serves as an artificial pancreas comprises a hollow fiber having an inner diameter of about 5 mm which is surrounded by islets of Langerhans enclosed in a housing. The islets are suspended in a semi-solid matrix which ensures desired distribution of the cells about the hollow fiber. The hollow fiber and suspended islets are enclosed in a housing which further aids the desired distribution of islets about the hollow fiber. The hollow fiber has a porosity which selectively allows passage of substances having a molecular weight of less than about 100,000 Daltons. The semi-solid matrix in which the islets are embedded and suspended is formed of an appropriate supporting material such as alginate or agar.

US Patent:

39795926, Sep 7, 1976

Filed:

Apr 17, 1975

Appl. No.:

5/569024

Inventors:

Edward J. Doherty - Halifax MA
David W. Morrison - Burlington MA

Assignee:

Raytheon Company - Lexington MA

International Classification:

G01T 116

US Classification:

250363S

Abstract:

A radiographic imaging system coupled to a movable table for repositioning subject matter at the conclusion of a scanning of an area of the subject matter. The imaging system is further coupled to a plural axis recording system in which a recording implement, such as a flashing light source, is driven in synchronism with a scanning motion of the imaging system along a recording medium such as a photographic film. Controller circuitry is coupled between the movable table, the imaging system and the recording system for synchronizing their respective operations and for selectably scaling the movement of a drive unit relative to the movement of the scanning. A large subject such as a complete human being may be scanned by repositioning the subject and the movable table at the conclusion of each of a sequence of area scans of the imaging system, and by scaling the output of the scanning system so that the successively scanned regions of the subject can be recorded upon a single standard size x-ray film plate.

US Patent:

41952278, Mar 25, 1980

Filed:

Jun 20, 1978

Appl. No.:

5/917356

Inventors:

Richard W. Carman - Foxboro MA
Edward J. Doherty - Halifax MA

Assignee:

Union Carbide Corporation - New York NY

International Classification:

G02B 500

US Classification:

250505

Abstract:

Scanning apparatus is provided for a movable array of highly focused collimators surrounding a scan field.

US Patent:

42130549, Jul 15, 1980

Filed:

Dec 30, 1977

Appl. No.:

5/866016

Inventors:

Edward J. Doherty - Halifax MA

Assignee:

Union Carbide Corporation - New York NY

International Classification:

G02B 500
G01T 120

US Classification:

250505

Abstract:

Scanning apparatus is provided for an array of highly focused collimators surrounding a scan field.

US Patent:

57862168, Jul 28, 1998

Filed:

Nov 10, 1994

Appl. No.:

8/337555

Inventors:

Keith E. Dionne - Rehoboth MA
Orion D. Hegre - Green Valley AZ
Thomas R. Flanagan - Barrington RI
Tyrone F. Hazlett - Coventry RI
Edward J. Doherty - Mansfield MA

Assignee:

Cytotherapeutics, Inc.

International Classification:

C12N 500
C12N 1104
A61K 952
A61K 950

US Classification:

435402

Abstract:

A biocompatible capsule for containing cells for implantation is prepared containing an inner support that provides tensile strength to the capsule. The capsule may be a tubular semipermeable membrane such as a hollow fiber membrane having both ends sealed. A rod shaped inner support extends through the lumen and ends of the rod are attached to sealed ends of the fiber. Prior to sealing one fiber end, cells are introduced into the lumen. Cells within the capsule may be suspended in a liquid medium or immobilized in a hydrogel or extracellular matrix material, and biologically active molecules can be delivered from the capsule to surroundings or from the surroundings into the capsule. The inner support may have external features such as flutes or a roughened or irregularly-shaped surface, and may be coated with cell-adhesive substance or a cell-viability-enhancing substance. The inner support may be a hollow tube having two channels, one communicating with a filling port that permits injecting cells through the support into the capsule and the other communicating with another port that allows gas to escape through the support as cells are introduced.

US Patent:

57732868, Jun 30, 1998

Filed:

May 24, 1995

Appl. No.:

8/449568

Inventors:

Keith E. Dionne - Rehoboth MA
Orion D. Hegre - Chepachet RI
Thomas R. Flanagan - Barrington RI
Tyrone F. Hazlett - Coventry RI
Edward J. Doherty - Mansfield MA

Assignee:

CytoTherapeutics, Inc. - Providence RI

International Classification:

C12N 500
C12N 1100
C12N 1104

US Classification:

4352971

Abstract:

A biocompatible capsule for containing cells for implantation is prepared containing an inner support that provides tensile strength to the capsule. Cells within the capsule are suspended in a liquid medium or immobilized in a hydrogel or extracellular matrix material, and are surrounded by a semipermeable membrane across which biologically active molecules can be delivered from the capsule to surroundings or from the surroundings into the capsule. The inner support may be formed as an integral part of the capsule during a coextrusion process to form the capsule. Alternatively, the inner support may be a discrete component within a tube having top and bottom sealing fittings that are linked withing the tube by the support. The inner support may have external features such as flutes or a roughened or irregularly-shaped surface, and may be coated with cell-adhesive substance or a cell-viability-enhancing substance. The inner support may be a hollow tube having two channels, one communicating with a filling port that permits injecting cells through the support into the capsule and the other communicating with another port that allows gas to escape through the support as cells are introduced.

US Patent:

20170246281, Aug 31, 2017

Filed:

Feb 16, 2017

Appl. No.:

15/434781

Inventors:

- Cambridge MA, US
Edward J. Doherty - Mansfield MA, US
Mark Cartwright - West Newton MA, US
Des White - Boston MA, US
Alexander G. Stafford - Revere MA, US
Omar Abdel-Rahman Ali - Cambridge MA, US
Amanda Graveline - Boston MA, US
Donald E. Ingber - Boston MA, US
David J. Mooney - Sudbury MA, US
Benjamin Seiler - Boston MA, US

International Classification:

A61K 39/108
A61K 39/02

Abstract:

The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.