Edward A Doherty

US Patent:

6337088, Jan 8, 2002

Filed:

Jun 5, 1995

Appl. No.:

08/465392

Inventors:

Frank T. Gentile - Warwick RI
Patrick A. Tresco - Sandy UT
Tyrone Hazlett - Coventry RI
Thomas Flanagan - Barrington RI
Edward J. Doherty - Mansfield MA
David Rein - Providence RI
Laura M. Holland - Ambler PA

Assignee:

Neurotech S.A. - Evry

International Classification:

A01N 6300

US Classification:

424451, 424400

Abstract:

A method for determining the viral retentivity of an external jacket of an implantable permselective macrocapsule. Viral retentivity describes the ability of an external jacket to retard the transport of virus particles across the jacket.

US Patent:

20010043923, Nov 22, 2001

Filed:

Mar 7, 2001

Appl. No.:

09/801237

Inventors:

Malcolm Schinstine - Ben Salem PA, US
Molly Shoichet - Toronto, CA
Frank Gentile - Warwick RI, US
Joseph Hammang - Barrington RI, US
Laura Holland - Horsham PA, US
Brian Cain - Everett MA, US
Edward Doherty - Mansfield MA, US
Shelley Winn - Smithfield RI, US
Patrick Aebischer - Lutry, CH

International Classification:

A61K048/00

US Classification:

424/093210

Abstract:

This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the BAO with ECM molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination.

US Patent:

20080262581, Oct 23, 2008

Filed:

Apr 17, 2008

Appl. No.:

12/104515

Inventors:

Michael S. Barsness - Oxford MA, US
Edward J. Doherty - Mansfield MA, US

Assignee:

Transport Pharmaceuticals, Inc. - Framingham MA

International Classification:

A61N 1/00

US Classification:

607115

Abstract:

An apparatus to monitor current density in the application of medicament to a treatment site of a mammalian user of a electrokinetic device including: an applicator cartridge including an active electrode, a matrix carrying a medicament or a medicament and an electrically conductive carrier; a device including an electrical power source connectable to the active electrode, a counter electrode, and an electronic circuit configured to control the application of electrical current through the active electrode to establish a conductive path extending from the power source, through the active electrode, matrix, the treatment site, the user and the counter electrode electrically connected to the power source, and an array of contacts monitoring current density flowing through the matrix and to the treatment site, wherein the array of sensors are arranged monitor the current density at various locations of the matrix and a contact area between the matrix and skin above the treatment site.

US Patent:

50026615, Mar 26, 1991

Filed:

Aug 25, 1989

Appl. No.:

7/398739

Inventors:

William L. Chick - Wellesley MA
Susan J. Sullivan - Newton MA
Kermit M. Borland - Worcester MA
John M. Harvey - Worcester MA
Thomas E. Muller - Concord MA
Karen E. Dunleavy - Billerica MA
Donald P. King - Haverhill MA
Edward J. Doherty - Waltham MA
Barry A. Solomon - Bedford MA
Amy L. Foley - Framingham MA

Assignee:

W. R. Grace & Co.-Conn. - Lexington MA

International Classification:

B01D 6306

US Classification:

210192

Abstract:

A device which serves as an artificial pancreas comprises a hollow fiber having an inner diameter of about 5 mm which is surrounded by islets of Langerhans enclosed in a housing. The islets are suspended in a semi-solid matrix which ensures desired distribution of the cells about the hollow fiber. The hollow fiber and suspended islets are enclosed in a housing which further aids the desired distribution of islets about the hollow fiber. The hollow fiber has a porosity which selectively allows passage of substances having a molecular weight of less than about 100,000 Daltons. The semi-solid matrix in which the islets are embedded and suspended is formed of an appropriate supporting material such as alginate or agar.

US Patent:

58537171, Dec 29, 1998

Filed:

May 23, 1995

Appl. No.:

8/447356

Inventors:

Malcolm Schinstine - Ben Salem PA
Molly S. Shoichet - Toronto, CA
Frank T. Gentile - Warwick RI
Joseph P. Hammang - Barrington RI
Laura M. Holland - Horsham PA
Brian M. Cain - Everett MA
Edward J. Doherty - Mansfield MA
Shelley R. Winn - Smithfield RI
Patrick Aebischer - Lutry, CA

Assignee:

CytoTherapeutics, Inc. - Lincoln RI

International Classification:

A01N 6300

US Classification:

424 9321

Abstract:

This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the BAO with ECM molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination.

US Patent:

58405763, Nov 24, 1998

Filed:

May 23, 1995

Appl. No.:

8/445193

Inventors:

Malcolm Schinstine - Ben Salem PA
Molly S. Shoichet - Toronto, CA
Frank T. Gentile - Warwick RI
Joseph P. Hammang - Barrington RI
Laura M. Holland - Horsham PA
Brian M. Cain - Everett MA
Edward J. Doherty - Mansfield MA
Shelley R. Winn - Smithfield RI
Patrick Aebischer - Lutry, CH

Assignee:

CytoTherapeutics, Inc.

International Classification:

C12N 500

US Classification:

435325

Abstract:

This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the BAO with ECM molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination.

US Patent:

58587470, Jan 12, 1999

Filed:

May 23, 1995

Appl. No.:

8/447810

Inventors:

Malcolm Schinstine - Ben Salem PA
Molly S. Shoichet - Toronto, CA
Frank T. Gentile - Warwick RI
Joseph P. Hammang - Barrington RI
Laura M. Holland - Horsham PA
Brian M. Cain - Everett MA
Edward J. Doherty - Mansfield MA
Shelley R. Winn - Smithfield RI
Patrick Aebischer - Lutry, CH

Assignee:

CytoTherapeutics, Inc.

International Classification:

C12N 1104
C12N 506
C12N 508
C12N 1102

US Classification:

435182

Abstract:

Methods and compositions are provided for controlling cell distribution within an implantable bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the bioartificial organ with extracellular matrix molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination. The bioartificial organ typically has a semipermeable membrane encapsulating a cell-containing core, and is preferably immunoisolatory.

US Patent:

59550953, Sep 21, 1999

Filed:

Aug 14, 1995

Appl. No.:

8/436281

Inventors:

Frank T. Gentile - Warwick RI
Tyrone Hazlett - Coventry RI
Patrick A. Tresco - Sandy UT
Thomas Flanagan - Barrington RI
Edward J. Doherty - Mansfield MA
David Rein - Providence RI
Laura M. Holland - Ambler PA

Assignee:

Brown University Research Foundation - Providence RI

International Classification:

A61K 948
A61F 1300

US Classification:

424422

Abstract:

Microporous macrocapsules are disclosed which are useful as implantation devices for cell therapy. The macrocapsule comprises living cells that secrete biological substance that are therapeutically useful and that are released from the macrocapsule to the site of implantation. The capsules can have selected permeability characteristics based upon their particular usage and desired viral retentivity characteristics.