Richard Tillyer - Cranford NJ, US Paul Reider - Westfield NJ, US Edward Grabowski - Westfield NJ, US Feng Xu - Staten Island NY, US Robert Wenslow - East Windsor NJ, US Jose Vega - Trappe PA, US Richard Varsolona - Scotch Plains NJ, US
International Classification:
C07C069/34 A61K031/225
US Classification:
514/548000, 560/146000
Abstract:
The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a crystalline hydrated form of the calcium salt of dihydroxy open acid simvastatin to a patient in need of such treatment. Methods for making the calcium salt of dihydroxy open acid simvastatin are also provided.
Dihydroxy Open-Acid And Salts Of Hmg-Co-A Reductase Inhibitors
Richard Tillyer - Cranford NJ, US Paul Reider - Westfield NJ, US Edward Grabowski - Westfield NJ, US Feng Xu - Staten Island NY, US Jose Vega - Trappe PA, US Mandana Asgharnejad - Ambler PA, US
Assignee:
Merck & Co., Inc.
International Classification:
A61K031/225 A61K009/22 A61K009/16 A61K009/50
US Classification:
424/468000, 514/548000
Abstract:
The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a compound selected from a dihydroxy open acid statin and a pharmaceutically acceptable salt or ester thereof in a delayed-release pharmaceutical dosage form to a patient in need of such treatment wherein substantial release of the compound from the dosage form is delayed until after passage of the dosage form through the stomach.
Richard Tillyer - Cranford NJ, US Paul Reider - Westfield NJ, US Edward Grabowski - Westfield NJ, US Feng Xu - Staten Island NY, US Robert Wenslow - East Windsor NJ, US Jose Vega - Trappe PA, US Richard Varsolona - Scotch Plains NJ, US
International Classification:
A61K031/225 C07C069/66
US Classification:
514548000, 560180000
Abstract:
The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a crystalline hydrated form of the calcium salt of dihydroxy open acid simvastatin to a patient in need of such treatment. Methods for making the calcium salt of dihydroxy open acid simvastatin are also provided.
Apurba Bhattacharya - Rahway NJ Alan W. Douglas - Monmouth Junction NJ Edward J. Grabowski - Westfield NJ Ulf H. Dolling - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07F 704
US Classification:
546 14
Abstract:
A process for dehydrogenating a compound of the formula ##STR1## which comprises reacting the compound with a silylating agent in the presence of a quinone to introduce a. DELTA. sup. 1 double bond.
Apurba Bhattacharya - Rahway NJ Alan W. Douglas - Monmouth Junction NJ Edward J. Grabowski - Westfield NJ Ulf H. Dolling - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3158 C07J 7300
US Classification:
546 77
Abstract:
A process for dehydrogenating a compound of the formula ##STR1## which comprises reacting the compound with a silylating agent in the presence of a quinone to introduce a. DELTA. sup. 1 double bond.
Asymmetric Synthesis Of (-)-6-Chloro-4-Cyclopropyl-Ethynyl-4-Trifluoromethyl-1,4-Dihydro-2H-3,1- Benzoxanzin-2-One
Andrew S. Thompson - Mountainside NJ Edward G. Corley - Old Bridge NJ Edward J.J. Grabowski - Westfield NJ Nobuyoshi Yasuda - Mountainside NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07C21100 C07C 5116
US Classification:
564321
Abstract:
An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.
Excalibur Publishing 2005 - 2014
Product Manager
Edward Grabowski Communications Limited 2005 - 2014
Director
Impressions Software Inc Apr 1989 - Feb 1994
Game Creation
John Lewis Partnership Feb 1979 - Mar 1989
Systems Analyst
Skills:
Game Development Game Design Video Games Computer Games Social Games Gameplay Online Gaming Mobile Devices Monetization
Interests:
Technology Composing Computer Games Games Music Film
Dec 2009 to 2000 Owner / BrokerState Farm Insurance Agent Scottsdale, AZ Jul 2008 to Dec 2009 Agent / Agency OwnerHi-Point Construction and Development Santa Fe, NM Apr 2004 to Jul 2008 Vice President and Chief Operations OfficerThe Capitol Group Realty Santa Fe, NM Apr 2002 to Jul 2008 President, Owner / BrokerRE/MAX One, Inc Santa Fe, NM May 1999 to Mar 2002 Associate BrokerRE/MAX One, Inc
2001 to 2001 International Executive ClubOffice of the Governor Santa Fe, NM Jan 1996 to Jun 1999 Director of Constituent ServicesEnterprise Rental/Leasing Company Lancaster, CA Feb 1994 to Jun 1995 Assistant Branch Manager
Education:
University of Southern California Los Angeles, CA Dec 1993 Bachelor of Arts in EconomicsCCIM Institute
Name / Title
Company / Classification
Phones & Addresses
Edward Grabowski Manager
GRABOWSKI AND ASSOCIATES, LLC
7630 E Starla Dr, Scottsdale, AZ 85255
Edward Grabowski
S J FOWLER REAL ESTATE INC Real Estate Agents
2200 E Camelback Rd STE 110, Phoenix, AZ 85016 6022648400
Edward J. Grabowski Vice-President
THE COLLECTORS CLUB Membership Organization
22 E 35 St, New York, NY 10016 2126830559
Youtube
Edward J. Grabowski - Mass of Christian Burial
We gather to mourn the loss of our friend and brother Ed. Ed was a tru...
Duration:
1h 23m 5s
Edward Grabowski's The Blue & The Gray - Over...
A DOS game published in 1993 set during the American Civil War the gam...
Duration:
1h 8m 58s
Edward Grabowski - Grand Prix Manager 2 - 1996
For those who wants to remind this classic formula one stable manager ...
Duration:
9m 58s
Edward Grabowski's The Blue & The Gray 1993 m...
BELOW THIS PARAGRAPH,YOU FIND MY FRIENDS YOUTUBE CHANNELS THAT HAVE VE...
Duration:
36s
Scottsdale AZ Real Estate Market Watch - June...
Curious about what's happening in the Scottsdale, AZ real estate marke...
Duration:
4m 21s
Three British Empire Talks presented by the C...
Guadeloupe Postal History: The British Carry the Mails by Edward Grabo...