Edward W Jacobs

US Patent:

20020065211, May 30, 2002

Filed:

Aug 23, 2001

Appl. No.:

09/938262

Inventors:

Edward Jacobs - Lexington MA, US
Carl Rausch - Belmont MA, US

Assignee:

Biopure Corporation - Cambridge MA

International Classification:

A01N061/00
C12Q001/00
G01N033/48

US Classification:

514/001000, 435/004000, 702/019000

Abstract:

At least one dose of polymerized hemoglobin is administered a vertebrate to increase tissue oxygenation, or maintain issue oxygenation, in an organ of a vertebrate wherein the organ has a reduced red blood cell flow, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance. The hemoglobin increases function of the organ.

US Patent:

20030049232, Mar 13, 2003

Filed:

Sep 10, 2001

Appl. No.:

09/950270

Inventors:

Thomas Page - Watertown MA, US
William Light - Natick MA, US
Edward Jacobs - Lexington MA, US

Assignee:

Biopure Corporation - Cambridge MA

International Classification:

A61K045/00
A61K038/42

US Classification:

424/093700, 514/006000

Abstract:

A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered to the patient simultaneously. Alternatively, the hemoglobin solution can be administered to the patient prior to administrating the stored red blood cells or the stored red blood cells can be administered to the patient prior to administering the hemoglobin solution. A composition of the invention includes stored red blood cells and a hemoglobin solution.

US Patent:

20030158091, Aug 21, 2003

Filed:

Jan 24, 2003

Appl. No.:

10/351977

Inventors:

Edward Jacobs - Lexington MA, US
Carl Rausch - Medford MA, US

Assignee:

Biopure Corporation - Cambridge MA

International Classification:

A61K038/42

US Classification:

514/006000

Abstract:

The present invention relates to a method of therapeutically, or prophylactically, treating a vertebrate to increase tissue oxygenation, or maintain issue oxygenation, in tissue of a vertebrate wherein the tissue has a reduced red blood cell flow, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance. The method comprises introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.

US Patent:

20050079162, Apr 14, 2005

Filed:

Oct 18, 2004

Appl. No.:

10/967475

Inventors:

Thomas Page - Watertown MA, US
William Light - Natick MA, US
Edward Jacobs - Lexington MA, US

Assignee:

Biopure Corporation - Cambridge MA

International Classification:

A01N063/00

US Classification:

424093700

Abstract:

A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered to the patient simultaneously. Alternatively, the hemoglobin solution can be administered to the patient prior to administrating the stored red blood cells or the stored red blood cells can be administered to the patient prior to administering the hemoglobin solution. A composition of the invention includes stored red blood cells and a hemoglobin solution.

US Patent:

58542094, Dec 29, 1998

Filed:

Mar 23, 1995

Appl. No.:

8/409337

Inventors:

Edward E. Jacobs - Lexington MA
Carl W. Rausch - Medford MA

Assignee:

Biopure Corporation - Cambridge MA

International Classification:

A61K 3714
C07K 302
C07K 322

US Classification:

514 6

Abstract:

The present invention relates to a method of therapeutically, or prophylactically, treating a vertebrate to increase tissue oxygenation, or maintain issue oxygenation, in tissue of a vertebrate wherein the tissue has a reduced red blood cell flow, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance. The method comprises introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.

US Patent:

46434100, Feb 17, 1987

Filed:

Apr 15, 1985

Appl. No.:

6/724181

Inventors:

Dennis Mudge - Cumberland RI
Joseph Coskie - Shrewsbury MA
Edward H. Jacobs - Holliston MA
David R. Harris - Pawtucket RI

Assignee:

American Machine & Science, Inc. - Park Ridge IL

International Classification:

B23Q 318

US Classification:

269 64

Abstract:

A coupling construction and a clamp therefor are disclosed which are operative with improved effectiveness in a workholding system for securing a workpiece at a work station. The coupling comprises a receiver and a carrier, and at least one of the clamps for securing the receiver and the carrier in a coupled position with high clamping pressures. The clamp comprises a clamp body, and a clamping element, a movable member, a spring assembly and an actuating assembly on the clamp body. The actuating assembly preferably includes a toggle member having oppositely facing knuckle elements thereon which are rotatably received in sockets for mounting the toggle member so that it is pivotable to actuate the spring assembly for biasing the movable member toward the clamping element. When the clamp is assembled in the coupling, and the receiver and the carrier are received in a coupled position between the clamping element and the movable member, the toggle member is pivotable to actuate the spring assembly for applying clamping pressures to the receiver and the carrier to secure them in the coupled position.