Edward T Roche

US Patent:

6482823, Nov 19, 2002

Filed:

Jun 21, 2000

Appl. No.:

09/598157

Inventors:

Danny Yu - Somervile NJ
Edward Roche - Paoli PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 31535

US Classification:

5142288, 5142302, 424489, 424497, 424494

Abstract:

A liquid composition for oral administration comprising a pharmaceutically active medicament coated with a taste masking effective amount of a polymer blend of (a) dimethylaminoethyl methacrylate and neutral methacrylic acid ester (MM/MAE) and (b) a cellulose ester, in an aqueous vehicle, wherein the polymer weight ratio of the cellulose ester to the MM/MAE is about 40:60 to about 90:10, preferably about 60:40. The liquid composition utilizes a âreverse enteric coatingâ which is soluble in the acid pHs of the stomach, generally about 1. 0 to 4. 0, but relatively insoluble at the non-acidic pHs of the mouth. The coatings provide for rapid release and absorption of the drug, which is generally desirable in the case of liquid dosage forms.

US Patent:

6586012, Jul 1, 2003

Filed:

Sep 24, 2002

Appl. No.:

10/253683

Inventors:

Danny Yu - Somervile NJ
Edward Roche - Paoli PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 914

US Classification:

424489, 424494, 424497

Abstract:

A liquid composition for oral administration comprising a pharmaceutically active medicament coated with a taste masking effective amount of a polymer blend of (a) dimethylaminoethyl methacrylate and neutral methacrylic acid ester (MM/MAE) and (b) a cellulose ester, in an aqueous vehicle, wherein the polymer weight ratio of the cellulose ester to the MM/MAE is about 40:60 to about 90:10, preferably about 60:40. The liquid composition utilizes a âreverse enteric coatingâ which is soluble in the acid pHs of the stomach, generally about 1. 0 to 4. 0, but relatively insoluble at the non-acidic pHs of the mouth. The coatings provide for rapid release and absorption of the drug, which is generally desirable in the case of liquid dosage forms.

US Patent:

8290581, Oct 16, 2012

Filed:

Oct 30, 2008

Appl. No.:

12/261410

Inventors:

Leo B. Kriksunov - Glenside PA, US
Aliya Z. Omer - Houston TX, US
Edward Roche - Paoli PA, US
Joshua Ghaim - Princeton NJ, US
Naomi Furgiuele - Doylestown PA, US

Assignee:

McNeil-PPC, Inc. - Skillman NJ

International Classification:

A61N 1/00
A61B 5/04
A61H 1/00

US Classification:

607 2, 607 3, 607 7, 607 46, 600372, 601 5

Abstract:

The present invention is directed to an apparatus that includes a microcurrent delivery device portion and at least one independent sensory cue delivery means. The independent sensory cue delivery means can provide an independent sensory cue selected from the group consisting of vibration, heat, cool, skin irritation, tingling, fragrance or auditory.

US Patent:

20130013028, Jan 10, 2013

Filed:

Sep 12, 2012

Appl. No.:

13/611079

Inventors:

Leo B. Kriksunov - Glenside PA, US
Aliya Z. Omer - Houston TX, US
Edward Roche - Paoli PA, US
Joshua Ghaim - Princeton NJ, US
Naomi Furgiule - Doylestown PA, US

Assignee:

MCNEIL-PPC,INC. - Skillman NJ

International Classification:

A61N 1/36

US Classification:

607 62

Abstract:

The present invention is directed to an apparatus that includes a microcurrent delivery device portion and at least one independent sensory cue delivery means. The independent sensory cue delivery means can provide an independent sensory cue selected from the group consisting of vibration, heat, cool, skin irritation, tingling, fragrance or auditory.

US Patent:

55995772, Feb 4, 1997

Filed:

May 31, 1995

Appl. No.:

8/455427

Inventors:

Charles A. Stevens - Lansdale PA
Michael R. Hoy - North Wales PA
Edward J. Roche - Paoli PA

Assignee:

McNeil-PPC, Inc. - Skillman NJ

International Classification:

B05D 312
A61K 924
A61J 300

US Classification:

427 214

Abstract:

A method of making solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier. The barrier is formed by coating with a polymer impermeable to simethicone.

US Patent:

54608252, Oct 24, 1995

Filed:

Jul 23, 1993

Appl. No.:

8/096791

Inventors:

Edward J. Roche - Paoli PA
Susan M. Papile - Blue Bell PA
Eleanor M. Freeman - Norristown PA

Assignee:

McNeil-PPC, Inc. - Milltown NJ

International Classification:

A61K 926

US Classification:

424470

Abstract:

Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of: medicament, e. g. famotidine; binder, e. g. HPMC; and carrier, e. g. lactose; and the rotogranules are coated with cellulose acetate, cellulose acetate butyrate or a combination thereof and hydroxypropyl cellulose. A process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules.

US Patent:

54894360, Feb 6, 1996

Filed:

Dec 13, 1993

Appl. No.:

8/166111

Inventors:

Michael R. Hoy - Sellersville PA
Edward J. Roche - Paoli PA

Assignee:

McNeil-PPC, Inc. - Milltown NJ

International Classification:

A61K 920

US Classification:

424441

Abstract:

Chewable tablets are made from a coated medicament wherein the coating comprises a mixture of dimethylaminoethyl methacrylate and neutral methacrylic acid ester and a cellulose ester, e. g. cellulose acetate, cellulose acetate butyrate, cellulose triacetate or a combination thereof and optionally polyvinyl pyrrolidone, and a process for making such tablets and a method of providing taste masking and sustained releasing of medicaments utilizing such coatings.

US Patent:

56793766, Oct 21, 1997

Filed:

May 31, 1995

Appl. No.:

8/455443

Inventors:

Charles A. Stevens - Lansdale PA
Michael R. Hoy - North Wales PA
Edward J. Roche - Paoli PA

Assignee:

McNeil-PPC, Inc. - Skillman NJ

International Classification:

A61K 924
A61K 926
A61K 952

US Classification:

424472

Abstract:

A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.