Efren D Santos

US Patent:

20090004185, Jan 1, 2009

Filed:

Jan 10, 2008

Appl. No.:

11/972237

Inventors:

Aranapakam M. VENKATESAN - Rego Park NY, US
Christoph DEHNHARDT - New York NY, US
Zecheng CHEN - New City NY, US
Osvaldo Dos SANTOS - Astoria NY, US
Efren Delos SANTOS - Nanuet NY, US
Kevin CURRAN - Congers NY, US
Lei CHEN - Hartsdale NY, US

Assignee:

WYETH - Madison NJ

International Classification:

C07D 239/95
A61K 31/498
C07D 401/02
C07D 403/02
C07D 413/02
A61K 31/5377
A61K 31/55
A61K 39/395
A61P 35/00

US Classification:

4241331, 544291, 5142664, 51426622, 51425217, 544284, 51421021, 5142345, 544119, 540600, 51421706

Abstract:

The present invention relates to amino-substituted quinazoline derivatives as inhibitors of β-catenin/tcf-4 pathway, which can be useful in the treatment of cancer; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

US Patent:

20030130238, Jul 10, 2003

Filed:

Nov 1, 2002

Appl. No.:

10/285940

Inventors:

Vincent Sandanayaka - Northboro MA, US
Efren Delos Santos - Nanuet NY, US

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

A61K031/66
C07F009/02
A61K031/55
C07D213/56
A61K031/40
A61K031/44

US Classification:

514/114000, 514/575000, 514/357000, 514/217120, 514/408000, 540/609000, 546/336000, 548/566000, 558/166000, 562/623000

Abstract:

Compounds of the formula are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease and HIV.