Elizabeth A Dodson

US Patent:

20110159013, Jun 30, 2011

Filed:

Oct 11, 2010

Appl. No.:

12/901738

Inventors:

Paul Acton - Newbury Park CA, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William L. Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kirsten Viola - Chicago IL, US
Lei Chang - Westmont IL, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 39/395
C07K 16/18
C12N 5/0793
G01N 33/53
A61P 25/28

US Classification:

4241721, 5303898, 5303882, 435375, 435 71, 436501

Abstract:

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.