Elizabeth A Dodson

US Patent:

7780963, Aug 24, 2010

Filed:

Oct 21, 2005

Appl. No.:

11/256332

Inventors:

Paul Acton - Quakertown PA, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Lei Chang - Westmont IL, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kirsten Viola - Chicago IL, US

Assignee:

Merck & Co., Inc. - Rahway NJ
Northwestern University - Evanston IL

International Classification:

A61K 39/395
C07K 16/18
G01N 33/53

US Classification:

4241331, 5303873, 435 72, 4241411

Abstract:

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β1-42.

US Patent:

7811563, Oct 12, 2010

Filed:

Oct 21, 2005

Appl. No.:

11/577426

Inventors:

Paul Acton - Quakertown PA, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William L Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kirsten Viola - Chicago IL, US
Lei Chang - Westmont IL, US

Assignee:

Northwestern University - Evanston IL
Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 39/395
C07K 16/18
G01N 33/53

US Classification:

4241331, 5303873, 435 72, 4241411

Abstract:

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

US Patent:

8383113, Feb 26, 2013

Filed:

Feb 8, 2012

Appl. No.:

13/368742

Inventors:

Paul Acton - Quakertown PA, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Lei Chang - Westmont IL, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kristen Viola - Chicago IL, US

Assignee:

Northwestern University - Evanston IL
Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 39/395
C07K 16/18
G01N 33/53

US Classification:

4241331, 5303873, 5303881, 435 72, 4241411

Abstract:

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

US Patent:

20100272714, Oct 28, 2010

Filed:

Jul 1, 2010

Appl. No.:

12/828411

Inventors:

Paul Acton - Quakertown PA, US
Zhiqiang An - Ambler PA, US
Andrew J. Bett - Lansdale PA, US
Robert Breese - Quakertown PA, US
Lei Chang - Westmont IL, US
Elizabeth Chen Dodson - Souderton PA, US
Gene Kinney - Collegeville PA, US
William Klein - Winetka IL, US
Mary P. Lambert - Glenview IL, US
Xiaoping Liang - Collegeville PA, US
Paul Shughrue - West Chester PA, US
William R. Strohl - Bridgewater NJ, US
Kristen Viola - Chicago IL, US

International Classification:

A61K 39/395
C07K 16/00
C12N 5/02
G01N 33/53

US Classification:

4241301, 5303871, 5303881, 435375, 435 71

Abstract:

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.